Results 181 to 190 of about 140,547 (317)

Current and possible future role of 3D modelling within oesophagogastric surgery: a scoping review protocol. [PDF]

open access: yesBMJ Open, 2021
Robb HD   +6 more
europepmc   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

open access: yesFEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke   +4 more
wiley   +1 more source

Unveiling ccTGA complexity: CMR and 3D modelling for surgical planning-a case series. [PDF]

open access: yesEur Heart J Imaging Methods Pract
Cao I   +13 more
europepmc   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

open access: yesFEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik   +6 more
wiley   +1 more source

3D modelēšanas metodes un problēmas [PDF]

open access: yes
Primārais konkrētās 3D modelēšanas tehnoloģijas izvēles iemesls ir atkarīgs no risināmā uzdevuma, izvirzītās gala modeļa precizitātes, operatora (projektētāja) spējām, programmatūras, datu apstrādes sistēmas fizikālās daļas. Inženierprojekta realizācijas
Lelamera, Jevgenija
core  

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

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