The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
SRE-FMaps: A Sinkhorn-Regularized Elastic Functional Map Framework for Non-Isometric 3D Shape Matching. [PDF]
Zhang D, Zhang Y, Wang N, Zhao D.
europepmc +1 more source
Exploration of piperidine 3D fragment chemical space: synthesis and 3D shape analysis of fragments derived from 20 regio- and diastereoisomers of methyl substituted pipecolinates. [PDF]
Jones SP +13 more
europepmc +1 more source
Targeting p38α in cancer: challenges, opportunities, and emerging strategies
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley +1 more source
Orientation fields predict human perception of 3D shape from shading. [PDF]
Aubuchon C +6 more
europepmc +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Programmable and Reversible 3D-to-3D Shape Transformation: Hierarchical Multimodal Morphing Based on Liquid Crystal Elastomers. [PDF]
Tian J, Shi C, Nie G, Li C, Zhao Y.
europepmc +1 more source
Shapebench: A New Approach to Benchmarking Local 3d Shape Descriptors
Bart Iver van Blokland
openalex +1 more source

