Results 71 to 80 of about 176,543 (244)

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

3D-Printed Multilayer Sensor Structure for Electrical Capacitance Tomography

Sensors, 2019
Presently, Electrical Capacitance Tomography (ECT) is positioned as a relatively mature and inexpensive tool for the diagnosis of non-conductive industrial processes.
Aleksandra Kowalska, Robert Banasiak, Andrzej Romanowski, Dominik Sankowski   +3 more
doaj   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

A novel 3D measurement technique for rigid moving objects with a determined movement trajectory and constant movement speed

AIP Advances, 2019
When phase-shifting (PS) and temporal-phase-unwrapping algorithms are employed for three-dimensional (3D) shape measurement, the measured object must be kept static during the projection and acquisition.
Jianhua Wang
doaj   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

PicoCam: High‐resolution 3D imaging of live animals and preserved specimens

Methods in Ecology and Evolution
The PicoCam system is a multi‐camera photogrammetry rig used for generating high‐resolution 3D models of animals in the field, or preserved specimens in laboratory or museum settings.
Josh Medina, Duncan Irschick, Kevin Epperly, David Cuban, Rosalee Elting, Lucas Mansfield, Nora Lee, Ana Melisa Fernandes, Felipe Garzón‐Agudelo, Alejandro Rico‐Guevara   +9 more
doaj   +1 more source

3D shape measurement influencing factors

, 2004
This paper presents a comparison of nondestructive measurement methods which are suitable for determination of the complete or partial shape and de-formations of real mechanical structures. First part of this paper presents a short overview and the major differences between the existing measurement methods together with theoretical principles of ...
Jecić, Stjepan, DRVAR, NENAD
openaire   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Color-encoded fringe projection for 3D shape measurements

Optics Express, 2007
A novel technique using color-encoded stripes embedded into a sinusoidal fringe pattern for finding the absolute shape of an object is proposed. Phases of the projected fringes on the surface are evaluated by Fourier transform method. Unwrapping is then performed with reference to the color-encoded stripes. When surfaces of interest contain large depth
openaire   +2 more sources