Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
A Phase Retrieval Method for 3D Shape Measurement of High-Reflectivity Surface Based on π Phase-Shifting Fringes. [PDF]
Sensors (Basel), 2023 Zhang Y, Sun J.
europepmc +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Robust Method for Position Measurement of Vertex of Polyhedron Using Shape from Focus
Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2010 A robust measurement method for measuring the vertex position of a small polyhedron using 3D image processing is proposed. The shape from focus method is applied for obtaining 3D positions of surfaces of the polyhedron.
Takashi HARADA
doaj +1 more source
Single-Shot Multi-Frequency 3D Shape Measurement for Discontinuous Surface Object Based on Deep Learning. [PDF]
Micromachines (Basel), 2023 Xu M, Zhang Y, Wan Y, Luo L, Peng J.
europepmc +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
3D point cloud data to quantitatively characterize size and shape of shrub crops
Horticulture Research, 2019 Crop breeding: 3D measurement of blueberry bush shape Researchers in the United States have developed a 3D imaging technique to quantitatively measure the shape of blueberry bushes in order to evaluate their suitability for mechanical harvesting.
Yu Jiang +5 more
doaj +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
ACCURACY EVALUATION FOR THE NON-CONTACT DEFECT AREA MEASUREMENT AT THE COMPLEX-SHAPE SURFACES UNDER VIDEOENDOSCOPIC CONTROL [PDF]
Научно-технический вестник информационных технологий, механики и оптики, 2014 The problem of non-contact surface defect area measurement at complex-shape objects under videoendoscopic control is considered. Major factors contributing to the measurement uncertainty are analyzed for the first time.
A. V. Gorevoy +2 more
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