Results 81 to 90 of about 6,997,548 (275)
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Jurnal Ilmu Komputer dan InformasiObject segmentation in 3D tomograms is a key problem in Cryo-Electron Tomography (Cryo-ET) analysis. In this work, performance for the 3D U-Net architecture, and its variants with three attention mechanisms (Attention Gate (AG), Squeeze-and-excitation ...
Ghessa Theniana +3 more
doaj +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
A Novel ConvLSTM-Based U-net for Improved Brain Tumor Segmentation
IEEE AccessUsing 2D scans or simple 3D convolutions are two limitations of previous works on segmentation of brain tumors by deep learning, which lead to ignoring the temporal distribution of the scans.
Osama Majeed Hilal Almiahi +2 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Semantic Segmentation of Brain Tumors Using 3D U-Net Architecture
, 2023 Zadatak ovog rada bio je istražiti i primijeniti metode dubokog učenja s ciljem segmentiranja mutimodalnih snimaka magnetske rezonancije mozga primjenom 3D U-Net arhitekture mreže. Opisani su temeljni pojmovi dubokog učenja i umjetnih neuronskih mreža, a
Kozina, Katarina
core
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
U-Net_dc: a novel U-Net-based model for endometrial cancer cell image segmentation
, 2023 Mutated cells may constitute a source of cancer. As an effective approach to quantifying the extent of cancer, cell image segmentation is of particular importance for understanding the mechanism of the disease, observing the degree of cancer cell lesions,
Zhanlin Ji (14016624) +6 more
core +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source