Results 41 to 50 of about 262,468 (192)

Analisis Implementasi Kebijakan Penertiban dan Pengelolaan Kebersihan Lingungan (Studi Kasus Pengelolaan Sampah Berbasis 3R di Kota Sungai Penuh)

Jurnal Ilmu Lingkungan
Kota Sungai Penuh telah menerapkan kebijakan penertiban dan pengelolaan kebersihan lingkungan sesuai dengan Peraturan Daerah (Perda) Nomor 7 Tahun 2017, yang didasarkan pada Undang-undang Nomor 18 Tahun 2008 tentang pengelolaan sampah berbasis Reuse ...
Hilda Mayang Sari, Aldri Afrinaldi
doaj   +1 more source

Dual Role of Tamoxifen in Enhancing STING and CEACAM1 Expression to Prime a Favorable Tumor Microenvironment for Anti‐TIM3 Immunotherapy

Advanced Science, EarlyView.
Anti‐PD‐1/PD‐L1 blockade has revolutionized cancer immunotherapy, but is ineffective against endocrine‐treated (i.e., Tamoxifen), relapsed ER+ breast cancer (BC) patients. This study provides insight into the sub‐optimal response of ER+BCs to anti‐PD‐1/PD‐L1 blockade – highlighting the induction of STING and the CEACAM1/TIM3 axis after chronic ...
Marvin Angelo E Aberin, Saurabh Singh, Soumya Chatterjee, Guang‐Zhi Sui, Yi‐Fu Wang, Ya‐Ting Lu, Yu‐Ling Lee, Kun‐Yuan Lin, Joy Khag, Ta‐Yu Liu, Shao‐Han Chang, Wai‐Mui Cheung, Hsiao‐Chin Hong, Ren‐Jun Hsu, Chen‐Yang Shen, Chia‐Wei Li, Weng‐Lang Yang, Yao‐Ming Chang, Shih‐Yu Chen, Chandan Guha, Shu‐Ping Wang   +20 more
wiley   +1 more source

BAP31 Drives Cartilage Calcification through Disruption of Autophagosome–Lysosome Fusion in Osteoarthritis

Advanced Science, EarlyView.
Mechanical stress activates BAP31 in chondrocytes. BAP31 competes with ATG14 for binding to STX17, disrupting the STX17–ATG14 complex required for autophagosome–lysosome fusion. The resultant autophagic flux blockade drives the generation of autophagy‐derived exosomes, which mediate pathological cartilage calcification in OA. Chondrocyte‐targeted BAP31
Zhi‐hua Xu, Ruo‐xin Wang, Feng He, Qian Liu, Fu‐yin Li, Min Hui, Yu‐qian Shi, Yu Jiang, Qing‐hua Li, Jun‐wen Jing, Shi‐bin Yu, Li‐tian Ma, Qian‐nan Niu, Mian Zhang   +13 more
wiley   +1 more source

Valores normativos do Balance Evaluation System Test(BESTest), Mini-BESTest, Brief-BESTest, Timed Up and Go Test e Usual Gait Speed em pessoas idosas Portuguesas saudáveis

Revista Portuguesa de Medicina Geral e Familiar, 2017
Objetivo: O objetivo deste estudo é estabelecer valores normativos relacionados com a idade e o género para o Balance Evaluation System Test (BESTest), Mini-BESTest, Brief-BESTest, Timed Up and Go (TUG) test e Usual Gait Speed (UGS) para a ...
Sara Isabel Lebre de Almeida, Alda Marques, Joana Santos   +2 more
doaj   +1 more source

Three repeat isoforms of tau inhibit assembly of four repeat tau filaments. [PDF]

PLoS ONE, 2010
Tauopathies are defined by assembly of the microtubule associated protein tau into filamentous tangles and classified by the predominant tau isoform within these aggregates.
Stephanie J Adams, Michael A DeTure, Melinda McBride, Dennis W Dickson, Leonard Petrucelli   +4 more
doaj   +1 more source

Atomic Defects in Layered Transition Metal Dichalcogenides for Sustainable Energy Storage and the Intelligent Trends in Data Analytics

Advanced Science, EarlyView.
This review comprehensively summarizes the atomic defects in TMDs for their applications in sustainable energy storage devices, along with the latest progress in ML methodologies for high‐throughput TEM data analysis, offering insights on how ML‐empowered microscopy facilitates bridging structure–property correlation and inspires knowledge for precise ...
Zheng Luo, Ying Yang, Zizhen Fu, Fengqi Liu, Susu Fang, Kele Xu, Shanshan Wang   +6 more
wiley   +1 more source

Microglial Deubiquitinase OTUD7B Stabilizes STAT3 to Promote Neuroinflammation and Cognitive Decline in Alzheimer's Disease

Advanced Science, EarlyView.
. ABSTRACT Neuroinflammation driven by microglial activation is a defining feature of Alzheimer's disease (AD), yet the molecular mechanisms sustaining this proinflammatory state remain unclear. Here, we identify the deubiquitinase OTUD7B as a critical regulator of microglial activation and AD pathology.
Luyao Li, Hao Tang, Qin Yu, Yuyang Zhang, Binglu Shi, Ying Kong, Leiyu Xu, Jingjing Shao, Chenghong Hu, Lingyu She, Zhe Wang, Haiyi Chen, Aleksandr V. Samorodov, Gang Cao, Xia Zhao, Yi Wang   +15 more
wiley   +1 more source

Sustainable Fabrication of Tailored Bone Substitutes: From High‐Throughput Scaffold Manufacturing, Scaled‐Up HMSC Expansion to Dynamic Cultivation in a Perfusion Bioreactor

Advanced Science, EarlyView.
ABSTRACT The demand for off‐the‐shelf biocompatible bone substitutes has driven the development of numerous independent in vitro technologies to generate products resembling physiological tissues. Due to technical challenges and overly simplified cultivation approaches/niches, the end‐products are often uniformly shaped and inferior to native bone ...
Franziska Braun, Anna Paříková, Sandra Rother, Martin Kantor, Salman Muhammad Ilyas, Ricardo Bernhardt, Pavel Ndjawa Yomi, Jaromír Havlica, Revathi Appali, Benjamin Kruppke, Poh Soo Lee   +10 more
wiley   +1 more source

Implementasi Pengelolaan Sampah Melalui Bank Sampah Kampus Dipo Waste Bank Universitas Diponegoro Menuju Green Campus

Jurnal Ilmu Lingkungan
Universitas Diponegoro merupakan salah satu universitas di Semarang yang menerapkan kampus hijau yang artinya Universitas Diponegoro memperhatikan permasalahan lingkungan.
Sri Sumiyati, M Arief Budiharjo, Anik Sarminingsih, Bima Setyadi Ramadhan, Ajeng Destiasari, Norrisal Fuade Anwar, Shabrina Putri Imani, Eriza Salsa Aldela, Ghina Azlia Prasasty, Hafidz Ismu Ramadhan, Asteria Marsha Firdausy, Nurul Fadhilah Zayanah   +11 more
doaj   +1 more source

Functional Disorder at the Neural Interface: How Disordered Nanostructures Promote Proper Growth and Differentiation in In Vitro Neural Cultures

Advanced Science, EarlyView.
This work provides a practical guide for neuroengineers to design advanced neural interfaces, embracing and tailoring the concept of functional disorder. By bridging 2D and 3D in vitro models, this work highlights how non‐periodic, spatially heterogeneous, multiscale nanotopography can enable more physiologically relevant platforms for studying neural ...
F. Maita, E. Palmieri, I. Lucarini, L. Montaina, L. Maiolo   +4 more
wiley   +1 more source