Results 91 to 100 of about 7,294,678 (325)
Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation
FEBS Letters, EarlyView.The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen +2 more
wiley +1 more source
Procedure for Handling 4-H Accounts: 4-H Financial Management
EDIS, 2007 4H5.1, a one-page factsheet by Marilyn N. Norman and Joy C. Jordan, introduces a series of factsheets designed to help 4-H leaders understand and correctly manage 4-H finances. Published by the UF Department of Family, Youth and Community Sciences, February 2007.
Marilyn N. Norman, Joy C. Jordan
openaire +3 more sources
EDIS, 1969 Good 4-H club programs don’t just happen. A lot of planning comes first. A 4-H club program plan serves as a road map of the club’s activities, helping to guide the club toward its goals. This publication was originally created by John A. Rutledge, Jr., August, 1985 and was revised by Joy C.
John Rutledge, Joy C. Jordan
openaire +5 more sources
ERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling
FEBS Letters, EarlyView.In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.
Chao Li +3 more
wiley +1 more source
4-H Energy Encounters Workbook
EDIS, 1969 Published by the Department of 4-H and Other Youth Programs, University of Florida Cooperative Extension, Institute of Food and Agricultural Sciences, November, 1992. Printed May, 1996; reviewed, June 2002. Reviewed November 2002.
Linda Barber +2 more
openaire +5 more sources
FEBS Letters, EarlyView.Knowing how proteases recognise preferred substrates facilitates matching proteases to applications. The S1′ pocket of protease EA1 directs cleavage to the N‐terminal side of hydrophobic residues, particularly leucine. The S1′ pocket of thermolysin differs from EA's at only one position (leucine in place of phenylalanine), which decreases cleavage ...
Grant R. Broomfield +3 more
wiley +1 more source
FEBS Letters, EarlyView.In this work, we reveal how different enzyme binding configurations influence the fluorescence decay of NAD(P)H in live cells using time‐resolved anisotropy imaging and fluorescence lifetime imaging microscopy (FLIM). Mathematical modelling shows that the redox states of the NAD and NADP pools govern these configurations, shaping their fluorescence ...
Thomas S. Blacker +8 more
wiley +1 more source
4-H Members and Firearms: The Case for 4-H Shooting Sports
Journal of Extension, 2019 As events of human violence emerge on the national stage and as individuals raise concerns about youths having access to firearms, it is important that Extension professionals, land-grant university administrators, and university legal counsels understand the guiding principles of the 4-H Shooting Sports program.
Goodwin, Jeff +2 more
openaire +2 more sources
FEBS Letters, EarlyView.C‐mannosylation is a unique form of protein glycosylation. In this study, we demonstrated that ADAMTS1 is C‐mannosylated at Trp562 and Trp565 in human testicular germ cell tumor NEC8 cells. We found that C‐mannosylation of ADAMTS1 is essential for its secretion, processing, enzymatic activity, and ability to promote vasculogenic mimicry. These findings
Takato Kobayashi +5 more
wiley +1 more source