Results 211 to 220 of about 6,848,602 (233)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

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Passport Adventures with 4-H: A STEM Curriculum for 4-H Clubs

2020
This curriculum is designed to focus on science, engineering and math through hands-on activities conducted in small group settings.
Tonya Bain, Charles Adams, Jennifer Richards   +2 more
openaire   +1 more source

4-H Lesson Plan: Exploring 4-H

2019
This lesson introduces students to the 4-H program. They learn about opportunities available to them including trips, project areas and activities. 4-H members will gain an understanding of the land-grant university system and how the 4-H program is run.
James Swart, Jennifer Richards
openaire   +1 more source

4-H Science: Building a 4-H Career Pathway Initiative

2018
Final report of the initiative to help youth develop STEM and workforce skills necessary for success, to immerse youth in the field of STEM work, and to engage youth with the science and engineering career pathway.
Joseph Donaldson, Karen Franck
openaire   +1 more source

4-H Presentations

2019
Provides information to help with preparing a 4-H presentation.
Jamison, Kathleen, Bonnett, Erika
openaire   +1 more source

The 4-H Organization

2022
Presentation on the history of Land-Grant Universities, Cooperative Extension, 4-H, and the organization of these entities.
openaire   +1 more source