Results 241 to 250 of about 29,450,134 (264)

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source

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Passport Adventures with 4-H: A STEM Curriculum for 4-H Clubs

2020
This curriculum is designed to focus on science, engineering and math through hands-on activities conducted in small group settings.
Tonya Bain, Charles Adams, Jennifer Richards   +2 more
openaire   +1 more source

4-H Lesson Plan: Exploring 4-H

2019
This lesson introduces students to the 4-H program. They learn about opportunities available to them including trips, project areas and activities. 4-H members will gain an understanding of the land-grant university system and how the 4-H program is run.
James Swart, Jennifer Richards
openaire   +1 more source

4-H Science: Building a 4-H Career Pathway Initiative

2018
Final report of the initiative to help youth develop STEM and workforce skills necessary for success, to immerse youth in the field of STEM work, and to engage youth with the science and engineering career pathway.
Joseph Donaldson, Karen Franck
openaire   +1 more source

4-H Lesson Plan: It's the Great Pumpkin, 4-H Brown

2018
This lesson uses exploration and a hands-on approach to aid students’ comprehension. The lesson begins with assessing students’ prior knowledge of measurement before encouraging students to creatively measure a pumpkin.
Aaron Spurling, Alexis Hall, Jennifer Richards   +2 more
openaire   +1 more source