Results 251 to 260 of about 5,090,387 (335)

The photoswitchable cannabinoid azo‐HU308 enables optical control of Ca2+ dynamics in INS‐1 β‐cells via off‐target effects on TRPC channels

FEBS Open Bio, EarlyView.
Light activation of the photoswitchable cannabinoid ligand azo‐HU308 triggers Ca2+ influx in pancreatic β‐cells through TRPC channels, independent of CB2 cannabinoid receptors. This reveals a non‐GPCR pathway for cannabinoid modulation of β‐cell Ca2+ dynamics and establishes azo‐HU308 as an optical tool to study cannabinoid signaling through TRP ...
Alexander E. G. Viray, James A. Frank
wiley   +1 more source

Spatial Heterogeneity of Metabolic Response to Drought Stress in <i>Medicago lupulina</i> L. Leaves. [PDF]

Metabolites
Wang X, Lv N, Xu Y, Meng X, Jin Y, Gao H, Li F, Yi Y, Liu L, Shen T.   +9 more
europepmc   +1 more source

Naked cuticle is essential for Drosophila wing development beyond Wingless signaling

FEBS Open Bio, EarlyView.
Naked cuticle (Nkd), a Wnt signaling inhibitor, assumes extensive roles in Drosophila wing development. Overexpressing Nkd causes smaller, crumpled wings, while also perturbing multiple signaling pathways and developmental genes. A specific region (R1S) is critical for Nkd's function as a signaling integrator, offering new insights for studying its ...
Rui Wang, Ping Wang
wiley   +1 more source

Identification and Characterization of Three Novel B-Cell Epitopes in African Swine Fever Virus p22 Protein. [PDF]

Microorganisms
Li Z, Zhou J, Chen Y, Liu H, Qi Y, Liang C, Zhu X, Liu E, Wu S, Ding P, Wang A.   +10 more
europepmc   +1 more source

Navigating new norms: a systematic review of factors for the development of effective digital tools in higher education

FEBS Open Bio, EarlyView.
What factors make for an effective digital learning tool in Higher Education? This systematic review identifies elements of a digital tool that published examples reveal to be features of an engaging and impactful digital tool. A systematic literature search yielded 25 research papers for analysis.
Akmal Arzeman, Jessica Haines, Connie Pritchard, Stephen Rutherford, Nigel Francis   +4 more
wiley   +1 more source

How to integrate patient and carer perspectives, methodological rigor, and ethics into biomedical research funding. [PDF]

PLoS Biol
Lichtenberg H, Müller C, Lindeman H, Ali L, Minheere A, van den Eijnden M, Dirnagl U.   +6 more
europepmc   +1 more source

Analysis of Treacher Collins syndrome 4‐associated mutations in Schizosaccharomyces pombe

FEBS Open Bio, EarlyView.
Fission yeast models carrying Treacher Collins syndrome type 4‐associated mutations reveal that impaired processivity of RNA polymerase I leads to defective rRNA transcription. This study highlights the essential role of a conserved arginine residue in Pol I elongation and provides mechanistic insight into the pathogenesis of ribosomopathies.
Kei Kawakami, Hiroaki Kato
wiley   +1 more source

Clinicopathologic and prognostic significance of TIAM2 overexpression in resected hepatocellular carcinoma. [PDF]

Future Sci OA
Lu J, Li L, Chen Q, Li B, Ren S, Yuan M, Meng M, Lei J, Bing Y, Wang H, Guo L, Ma Z, Xiu D, Yuan C.   +13 more
europepmc   +1 more source

Establishment of a coculture system for Porphyromonas gingivalis and head and neck squamous cell carcinoma using spheroid culture and LATS inhibition

FEBS Open Bio, EarlyView.
We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima, Shogo Okazaki, Muneaki Tamura, Shuichi Sato, Kenichi Imai   +4 more
wiley   +1 more source

High expression of GRB14 is associated with cancer progression and poor prognosis in gastric cancer. [PDF]

Discov Oncol
Hu H, Feng X, Zou Y, Jia X, Yang H, Luo X.   +5 more
europepmc   +1 more source