Results 231 to 240 of about 7,227 (274)

Synthesis of 1, 3, 4-Oxadiazole

Asian Journal of Research in Chemistry, 2017
Synthesis of 1, 3, 4-oxadiazole by the reaction of 2-propyl Benzo imidiazol-2-yl carbohydrazide and 1, 3, dihydro iso indo-2-yl acetic acid (Phthalyl Amino Acids) in presence of HCl and phosphoryl chloride. All the newly synthesized compounds were screened antibacterial activity which shows moderate to mild activity, and yield of the synthesized ...
Maqdoom Farooqui, Syed Nazimuddin
openaire   +1 more source

Study on 1, 3, 4-Oxadiazole Derivatives as an Antibacterial and Antifungal Agents

2021
In the present investigation a new series of 1, 3, 4-oxadiazoles (3a-j) were synthesized by reacting INH (1) and substituted aromatic acids (2) in presence of POCl3. The new compounds were established on the basis of IR, 1H NMR and Mass spectral data.
B. C. Revanasiddappa, E. V. S. Subrahmanyam   +1 more
openaire   +1 more source

Synthesis and study of poly (1, 3, 4-oxadiazoles)

Chemistry of Heterocyclic Compounds, 1967
Various conditions for synthesizing poly (1,3,4-oxadiazoles) from carboxylic acids, their hydrazides, and polyhydrazides, are investigated. Methods of cyclodehydration of polyhydrazides using phosphorus oxychloride, sulfuric acid, and certain other reagents are not of general utility for synthesizing poly (1,3,4-oxadiazoles).
A. P. Grekov, S. A. Malyutenko, K. A. Kornev   +2 more
openaire   +1 more source

A OVERVIEW ON ANTIMICROBIAL AND ANTI-INFLAMMATORY ACTIVITY OF 1, 3, 4-OXADIAZOLES

INDIAN DRUGS, 2020
1, 3, 4-oxadiazoles first came into the lime light about 80 years ago. With the increasing world population, the number of microbial infections has increased all over. To overcome the continuously spreading harmful microbial infections, the need for newer and newer drugs has increased tremendously.
Satvir Singh, Manpreet Kaur, Divya Bhandari, Mandeep Kaur, Monika Gupta   +4 more
openaire   +1 more source

SYNTHESIS AND ANTIMICROBIAL ACTIVITIES OF SOME NEW 1, 3, 4-OXADIAZOLES

INDIAN DRUGS, 2012
Various 5-β-[(N-Benzenesulphonyl/tosyl)-4-(un) substituted anilino] ethyl-2-H/CH3/C6H5/-CH2C6H5/p-NO2C6H4-1,3,4-oxadiazoles (5a-d), 5--β-[(N-Benzenesulphonyl/tosyl)-4-(un)-substituted anilino] ethyl-2-(N,N-diethylamino/anilino/morpholino)-1, 3, 4-oxadiazoles (6a-r), 3--β-[(N-Benzenesulphonyl/tosyl)-4-(un) substituted anilino] ethyl-4-amino-5-mercapto-4(
S Desai, U. Laddi
openaire   +1 more source

Recent Advances in 1, 3, 4-Oxadiazole Chemistry

1967
Publisher Summary This chapter introduces the chemistry of the 1,3,4-oxadiazoles. The 1,3,4-oxadiazoles have large number of applications in diverse areas—for example, in drug syntheses, scintillation materials, and the dyestuffs industry. Ring cleavage reactions of the 1,3,4-oxadiazoles have also excited great interest in various fields, because ...
A. Hetzheim, K. Möckel
openaire   +1 more source

1, 2, 4-Oxadiazoles

1976
Publisher Summary This chapter focuses on the chemistry of 1,2,4-oxadiazoles and the corresponding reduced derivatives. The chapter discusses the synthesis of 1,2,4-oxadiazoles. Two widely used general methods of synthesizing 1,2,4-oxadiazoles embrace 95% of the practical preparations of these compounds: The conversion of amidoximes by means of ...
openaire   +1 more source

Investigation of 1, 3, 4-Oxadiazole Scaffold as Potentially Active Compounds

International Journal of Drug Design and Discovery, 2011
In the present work, various Schiff’s bases of isoniazid bearing 1, 3, 4-oxadiazole nucleus were synthesized. These compounds were purified, characterized and evaluated in vitro for antibacterial, antifungal and antiviral activities. Compound 5 showed better biological profile.
Rakesh R. Somani, Anuj G. Agrawal, Pushkar P. Kalantri, Pratibha S. Gavarkar, Erik De Clercq   +4 more
openaire   +1 more source

Synthesis and biological evaluation of 1, 2, 4‐oxadiazole derivatives as novel GPR119 agonists

Chemical Biology & Drug Design, 2016
A series of 1, 2, 4‐oxadiazole derivatives have been designed and synthesized, and 25 compounds were evaluated their abilities by the assay of cAMP concentration in GPR119‐transfected HEK293T cells. All compounds showed acceptable agonistic effects on GPR119. Among these compounds, 4p exhibited the best agonistic effects with the EC50 of 20.6 nm, which
Suhong, Fu, Wei, Xiang, Jinying, Chen, Liang, Ma, Lijuan, Chen   +4 more
openaire   +2 more sources

Synthesis of Some New 1, 3, 4-Oxadiazole, Pyrazole, and Pyrimidine Bearing Thienopyrazole Moieties

Current Organic Synthesis, 2020
Aim and Objective: According to the literature survey, pyrazole is a unique template that is associated with several biological activities. This article highlighted the research work of many researchers reported in the literature for synthesis and different pharmacological activities of the pyrazole nucleus.
Mohamed Ahmed Elian Sophy, Mohamed Ahmed Mahmoud Abdel Reheim   +1 more
openaire   +2 more sources