Results 191 to 200 of about 112,447 (225)

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Spectroscopic and Electrical Insights into Humidity-Induced Modifications of Graphene Structures. [PDF]

ACS Omega
Sobola D, Kaspar P, Papež N, Dallaev R, Holcman V, Fohlerová Z, Sedlák P, Al-Anber MA, Macků R.   +8 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Opto-Electrochemical Probes for In Vitro/In Vivo Analysis: Principles, Designs, and Applications. [PDF]

Biosensors (Basel)
Vaneev AN, Gorelkin PV, Klyachko NL, Erofeev AS.   +3 more
europepmc   +1 more source

Flexible bioelectronic sensors promote the advancement of wearable ultrasound technology in the medicine. [PDF]

Microsyst Nanoeng
Li J, Li G, Ma C, Li W, Yu G, Xiang L, Yao G.   +6 more
europepmc   +1 more source

Modular Open-Source Stirred Tank Reactor (MOSTR), an Internet of Things (IoT) system for engineering education. [PDF]

HardwareX
Bangert K, Browncross E, Omar C.
europepmc   +1 more source

Continuous monitoring of blood-interstitial fluid intercompartmental molecular kinetics in freely moving animals. [PDF]

Sci Adv
Chen Y, Hu Q, Kwak JW, Zakharian D, Ji J, Liu D, Gopalan D, Lyons C, Yates M, Yee S, Cui H, Eisenstein M, Soh HT.   +12 more
europepmc   +1 more source

Anisotropic Magnetoresistive Sensors: Dynamic Modeling and Characterization for Blade Tip-Timing Measurements. [PDF]

Sensors (Basel)
Busti D, Capponi L, Gaspari A, Fabbiano L, Rossi G.   +4 more
europepmc   +1 more source

Photoelectric Composite Three-Phase Flow Sensor for Complex Oil and Gas Wells. [PDF]

Sensors (Basel)
Chen Q, Qiao X, Chen T, Gao H, Li C.
europepmc   +1 more source