Results 71 to 80 of about 1,345,776 (246)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Intelligent Autonomous Pollination for Future Farming - A Micro Air Vehicle Conceptual Framework With Artificial Intelligence and Human-in-the-Loop

IEEE Access, 2019
Food security is one of the societal challenge topics. As one-third of all food consumed by humans relies on animal pollination currently, this research provides an emerging solution to food supply reduction caused by population shrinking of natural ...
Yi Chen, Yun Li
doaj   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Voice-Based Detection of Parkinson’s Disease Using Machine and Deep Learning Approaches: A Systematic Review

Bioengineering
Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by motor and non-motor symptoms, among which vocal impairment is one of the earliest and most prevalent. In recent years, voice analysis supported by machine learning (ML)
Hadi Sedigh Malekroodi, Byeong-il Lee, Myunggi Yi   +2 more
doaj   +1 more source

Battery Remaining Useful Life Prediction with Inheritance Particle Filtering

Energies, 2019
Accurately forecasting a battery’s remaining useful life (RUL) plays an important role in the prognostics and health management of rechargeable batteries. An effective forecast is reported using a particle filter (PF), but it currently suffers from
Lin Li, Alfredo Alan Flores Saldivar, Yun Bai, Yun Li   +3 more
doaj   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Multi-Domain CoP Feature Analysis of Functional Mobility for Parkinson’s Disease Detection Using Wearable Pressure Insoles

Sensors
Parkinson’s disease (PD) impairs balance and gait through neuromotor dysfunction, yet conventional assessments often overlook subtle postural deficits during dynamic tasks.
Thathsara Nanayakkara, H. M. K. K. M. B. Herath, Hadi Sedigh Malekroodi, Nuwan Madusanka, Myunggi Yi, Byeong-il Lee   +5 more
doaj   +1 more source

Interfaces of the Agriculture 4.0

Proceedings of the 15th International Conference on Web Information Systems and Technologies, 2019
The introduction of information technologies in the environmental field is impacting and changing even a traditional sector like agriculture. Nevertheless, Agriculture 4.0 and data-driven decisions should meet user needs and expectations. The paper presents a broad theoretical overview, discussing both the strategic role of design applied to Agri-tech ...
Letizia Bollini, Alessio Caccamo, Carlo Martino   +2 more
openaire   +2 more sources

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source