Chimeric diphtheria toxin–CCL8 cytotoxic peptide for breast cancer management
Molecular Oncology, EarlyView.DTCCL8 is a recombinant fusion toxin that targets cancer cells expressing chemokine receptors. By combining diphtheria toxin with CCL8, DTCCL8 binds to multiple receptors on tumor cells and induces selective cytotoxicity. This strategy enables receptor‐mediated targeting of cancer and may support the development of chemokine‐guided therapeutics ...
Bernardo Chavez +5 more
wiley +1 more source
Molecular Oncology, EarlyView.Small extracellular vesicles are a promising source of diagnostic molecules. We conducted a comprehensive study, including transcriptome profiling and RT‐qPCR validation on large cohorts of samples. Diagnostic panels enabling sensitive detection of colorectal cancer and precancerous lesions were established. Some molecules were differentially expressed
Petra Vychytilova‐Faltejskova +26 more
wiley +1 more source
The Effect Of Adobe Flash Based Educating Game On Cognitive Capability Of Early Age Children In Tk Aisyiyah I Gumpang [PDF]
, 2013 This research was intended to study whether Adobe Flash based education game can improve cognitive capability of early age children in TK Aisyiyah I Gumpang class B, particularly in simple number recognition subject.
Aulia, Irfani
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β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Talent Investments Pay Off: Executive Briefing - Advocate Health Care Realizes Returns for Investments in Education Assistance [PDF]
, 2016 An analysis of Advocate Health Care's Education Assistance Program (EAP), conducted by Accenture and partner Lumina Foundation, shows a 4-percent return on every dollar invested in tuition assistance for the health system.
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Molecular Oncology, EarlyView.Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh +5 more
wiley +1 more source
Book Review of Gearon, Liam: On Holy Ground - the Theory and Practice of Religious Education
, 2012 Excerpt: With On Holy Ground, Routledge adds a thoughtful and welcome volume to its growing list of titles related to religious education and Christian education .Gearon begins by taking his readers on a sobering tour of the rejection of the sacred ...
Badley, Ken
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Autism Academy CourseWare: Behavioral Programming for Children with Autism, Eden II Programs, 1999, Digital Vista, Massapequa, NY, Computerized CD‐ROM. System requirements: Windows 95/98/NT, PC Pentium 120 MHz, 32 MB RAM, 4 × CD player, Sound Blaster sound card, 256 color display monitor. $149.00 (personal orders) or $399 per three‐pack (education programs)+shipping [PDF]
, 2002 Kimberly A. Schreck
openalex +1 more source
Molecular Oncology, EarlyView.RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha +10 more
wiley +1 more source
Promoting widening participation and higher education: Lessons from a four year intervention programme [PDF]
, 2008 Since the labour government came to power in 1997, a major policy has been to increase the participation rates of those entering higher education, particularly those from lower-socio economic backgrounds. Just over 10 years later, little has changed. The
Pinheiro-Torres, C, Portman-Smith, C
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