Results 281 to 290 of about 2,478,339 (383)

(Nie)porządek racjonalności. Refleksje wokół książki Conflicting Values of Inquiry. Ideologies of Epistemology in Early Modern Europe, eds. by Tamás Demeter, Kathryn Murphy, Claus Zittel, Leiden–Boston [2015], Brill, ss. XVII + 410

, 2018
Adam Chmielewski
openalex   +2 more sources

Targeting DAP5 Disrupts Alternate Mode of Translational Initiation in Tregs and Potentiates Antitumor Immunity

Advanced Science, EarlyView.
Regulatory T cells (Tregs) suppress antitumor immunity. This study identifies that the translation scaffold DAP5/eIF4G2 is upregulated in tumor‐infiltrating Tregs (ti‐Tregs). DAP5 mediates an alternate translation mode to sustain CD25 and MCL‐1 expression, which is critical for ti‐Treg stability and survival in the tumor microenvironment.
Xiaojiang Lai, Guihong Pan, Xixi Feng, Jun Zhang, Yunxia Li, Shanmeizi Zhao, Zhenming Lin, Yun Feng, Wei Bao, Hongyan Yang, Chengmei Xie, Chen Huang, Jun Wang   +12 more
wiley   +1 more source

Multispectral reflectance dataset of medicinal <i>Cannabis sativa</i> cultivars for varietal classification. [PDF]

Data Brief
Henao-Céspedes V, Cardona-Morales O, Vargas-Alzate JA, León-Zuleta JR, Garcés-Gómez YA.   +4 more
europepmc   +1 more source

410) The Play Places in a Crowded Residential District (Part 1)(Towen Planning・Economics・Proofing)

, 1956
Kichiemon Kawana, Masahisa Miwa, Kazuo Saito, Yasuo Kamata   +3 more
openalex   +2 more sources

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Wire-assisted modification of Havst catheter stripping of the great saphenous vein trunk. [PDF]

Front Surg
Lin X, Li P, Zhuang L.
europepmc   +1 more source

Synergistic Activation of Immunogenic Cell Death and the cGAS–STING Pathway by Engineered Zinc/Manganese‐Based Metal–Organic Framework Nanoplatforms for Colon Cancer Immunotherapy

Advanced Science, EarlyView.
A zinc/manganese (Zn/Mn)‐based metal‐organic framework (MOF) loaded with the STING agonist c‐di‐AMP diammonium (denoted AMP@Zn/Mn‐MOF) was developed to synergistically activate the cGAS‐STING pathway and induce immunogenic cell death. This nanoplatform reprograms the immunosuppressive tumor microenvironment, significantly enhancing anti‐PD‐L1 ...
Bingzi Zhu, Xiaodong Chen, Chang Xu, Xuehua Qian, Binglong Bai, Ji Lin, Wenhai Deng, Xiang Wang, Yuekai Cui, Shengsheng Zhao, Zuoliang Xie, Tao You, Yingpeng Huang, Xian Shen, Xufeng Lu, Weijian Sun   +15 more
wiley   +1 more source

The Effect of Tinted Filters on the Visual Function of Patients with Retinitis Pigmentosa. [PDF]

J Ophthalmic Vis Res
Riazifar A, Mirzajani A, Hashemi H, Jamali A, Khabazkhoob M, Bahreini R, Yekta A, Jafarzadehpur E.   +7 more
europepmc   +1 more source

Minerals of Britain and Ireland 2009–2024 by A.G. Tindle and D.I. Green. ISBN 978-1-83654-410-4, Distributed by The Russell Society, UK [PDF]

Jana Horák
openalex   +1 more source

Dual Aptamers‐Based SETDB1 PROTACs as Effective Anti‐Tumor Strategies for Breast Cancer

Advanced Science, EarlyView.
This study establishes dual‐aptamer PROTACs targeting SETDB1 using a SETDB1‐specific aptamer conjugated to AS1411. The designed PROTACs penetrate cells, recruit MDM2 to degrade SETDB1, and inhibit cancer cell proliferation and migration. Remarkably, they also overcome tamoxifen resistance and enhance CD8+ T cell cytotoxicity, suppressing tumor growth ...
Yanxuan Guo, Yingge Lv, Shuyu Huang, Chang Liu, Yan Ouyang, Bei Lan, Chenghao Xuan   +6 more
wiley   +1 more source