Results 81 to 90 of about 2,478,339 (383)

Time-Resolved Effect of Interferon-Alpha 2a on Activities of Nuclear Factor Kappa B, Pregnane X Receptor and on Drug Disposition Genes

Pharmaceutics, 2021
Interferon-alpha (IFN-α) is suggested to cause pharmacokinetic drug interactions by lowering expression of drug disposition genes through affecting the activities of nuclear factor kappa B (NF-ĸB) and pregnane X receptor (PXR).
Dirk Theile, Lelia Wagner, Cindy Bay, Walter Emil Haefeli, Johanna Weiss   +4 more
doaj   +1 more source

The role of language in mathematical development: Evidence from children with specific language impairments [PDF]

, 2007
A sample (n=48) of eight year olds with Specific Language Impairments is compared with age-matched (n=55) and language matched controls (n=55) on a range of tasks designed to test the interdependence of language and mathematical development.
Cowan, Richard, Donlan, Chris, Lloyd, Delyth, Newton, Elizabeth   +3 more
core   +2 more sources

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Lineage-dependent role of miR-410-3p as oncomiR in gonadotroph and corticotroph pituitary adenomas or tumor suppressor miR in somatotroph adenomas via MAPK, PTEN/AKT, and STAT3 signaling pathways

Endocrine, 2019
PurposemiR-410-3p plays opposite roles in different cancers and may act as an oncomiR or tumor suppressor miR. The purpose of this study was to assess the role of miR-410-3p in somatotroph, gonadotroph, and corticotroph pituitary adenomas.MethodsTissue ...
T. Grzywa, Klaudia Klicka, B. Rak, Dawid Mehlich, Filip Garbicz, G. Zieliński, M. Maksymowicz, E. Sajjad, P. Włodarski   +8 more
semanticscholar   +1 more source

Visual Recovery Reflects Cortical MeCP2 Sensitivity in Rett Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rett syndrome (RTT) is a devastating neurodevelopmental disorder with developmental regression affecting motor, sensory, and cognitive functions. Sensory disruptions contribute to the complex behavioral and cognitive difficulties and represent an important target for therapeutic interventions.
Alex Joseph Simon, Nathalie Picard, Valeria d'Andrea, Enchi Chang, Joseph Leffler, Eleonora Centofante, Matthew Taylor, Francesca Bardi, Francesca Cavicchiolo, Takao K. Hensch, Stefano Panzeri, Chinfei Chen, Michela Fagiolini   +12 more
wiley   +1 more source

Subtype-specific differentiation of cardiac pacemaker cell clusters from human induced pluripotent stem cells

Stem Cell Research & Therapy, 2017
Background Human induced pluripotent stem cells (hiPSC) harbor the potential to differentiate into diverse cardiac cell types. Previous experimental efforts were primarily directed at the generation of hiPSC-derived cells with ventricular cardiomyocyte ...
Patrick A. Schweizer, Fabrice F. Darche, Nina D. Ullrich, Pascal Geschwill, Boris Greber, Rasmus Rivinius, Claudia Seyler, Karin Müller-Decker, Andreas Draguhn, Jochen Utikal, Michael Koenen, Hugo A. Katus, Dierk Thomas   +12 more
doaj   +1 more source

Bioanalysis of the Ex Vivo Labile PACE4 Inhibitory Peptide Ac-[d-Leu]LLLRVK-Amba in Whole Blood Using Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry Quantification

Pharmaceutics, 2023
The calcium-dependent serine endoprotease PACE4 is evaluated as a therapeutic target for prostate cancer. The peptide Ac-[d-Leu]LLLRVK-amba inhibits PACE4 with high affinity and has shown efficacy in preclinical mice xenograft models of prostate cancer ...
Max Sauter, Jonas Haag, Cindy Bay, Florian Leuschner, Walter E. Haefeli, Tim Christian Kuhn, Jürgen Burhenne   +6 more
doaj   +1 more source

Lessons Learned: Quality Analysis of Optical Coherence Tomography in Neuromyelitis Optica

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Optical coherence tomography (OCT)‐derived retina measurements are markers for neuroaxonal visual pathway status. High‐quality OCT scans are essential for reliable measurements, but their acquisition is particularly challenging in eyes with severe visual impairment, as often observed in neuromyelitis optica spectrum disorders ...
Hadi Salih, Sara Samadzadeh, Charlotte Bereuter, Seyedamirhosein Motamedi, Claudia Chien, Pablo Villoslada, Hadas Stiebel‐Kalish, Nasrin Asgari, Yang Mao‐Draayer, Marius Ringelstein, Joachim Havla, Marco Aurélio Lana Peixoto, Ho Jin Kim, Jacqueline Palace, Maria Isabel Leite, Srilakshmi M. Sharma, Fereshteh Ashtari, Rahele Kafieh, Lekha Pandit, Orhan Aktas, Philipp Albrecht, Letizia Leocani, Itay Lotan, Sasitorn Siritho, Jérôme de Seze, Romain Marignier, Caroline Froment Tilikete, Denis Bernardi Bichuetti, Ivan Maynart Tavares, Ayse Altintas, Anu Jacob, Saif Huda, Ibis Soto de Castillo, Lawrence J. Cook, Michael R. Yeaman, Axel Petzold, Alexander U. Brandt, Friedemann Paul, Frederike C. Oertel, Hanna G. Zimmermann, with the Guthy Jackson Charitable Foundation—International Clinical Consortium and CROCTINO Collaborators   +40 more
wiley   +1 more source

Upper mantle P velocity structure beneath the Midwestern United States derived from triplicated waveforms [PDF]

, 2012
Upper mantle seismic velocity structures in both vertical and horizontal directions are key to understanding the structure and mechanics of tectonic plates.
Chu, Risheng, Helmberger, Don V., Schmandt, Brandon   +2 more
core  

Experimental Study of the Radiative Decays K+ -> mu+ nu e+e- and K+ -> e+ nu e+e-

, 2002
Experiment 865 at the Brookhaven AGS obtained 410 K+ -> e+ nu e+e- and 2679 K+ -> mu+ nu e+e- events including 10% and 19% background. The branching ratios were measured to be (2.48+-0.14(stat.)+-0.14(syst.))x10^-8 (m_ee>150 MeV) and (7.06+-0.16+-0.26 ...
A. A. Poblaguev, A. Sher, A. A. Poblaguev, A. M. Diamant-Berger, B. Bassalleck, D. Bardin, D. E. Kraus, D. Groom, D. M. Lazarus, D. R. Bergman, E. Gabrielli, G. S. Atoyan, H. Do, H. Kaspar, H. Ma, J. A. Thompson, J. Bijnens, J. Egger, J. Gasser, J. Gasser, J. Heintze, J. Lowe, J. Lozano, K. Heard, M. Chizhov, M. E. Zeller, N. Cheung, P. Lichard, P. Rehak, P. Truöl, R. Appel, R. Appel, S. Akimenko, S. Amendolia, S. Amendolia, S. Dhawan, S. Eilerts, S. Pislak, S. Weinberg, V. Belyaev, V. Bolotov, V. V. Issakov, W. Herold, W. Majid   +43 more
core   +1 more source