Results 71 to 80 of about 1,297,917 (256)
“Pushing Their Necks Out”: Ultra, The Black Watch, and Command Relations, May-sur-Orne, Normandy, 5 August 1944 [PDF]
, 2012 In 1974 Group Captain Frederick Winterbotham shocked the world when he revealed in his semiautobiographical work, The Ultra Secret, that the Allies had been breaking high-grade German ciphers throughout the greater portion of the Second World War in an ...
O\u27Keefe, David R.
core +1 more source
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
God Moves in a Mysterious Way : Public Discourse on Providence and the Battle of Gettysburg
, 2002 This study of public reaction to the Battle of Gettysburg in the context of the wider experience of the American Civil War focuses on the view of Providence in history and war.
Andrews, Sarah Marie
core
Molecular Oncology, EarlyView.This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert +13 more
wiley +1 more source
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source
Molecular Oncology, EarlyView.This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad +17 more
wiley +1 more source
Colonel Utley\u27s Emancipation - Or, How Lincoln Offered to Buy a Slave
, 2010 The reputation of Abraham Lincoln has see-sawed over the last half-century on the fulcrum of race, and the results have not been happy for that reputation.
Giles, Jerrica A., Guelzo, Allen C.
core
The Corps of Guides, 1903–1914 [PDF]
, 2012 The Canadian Corps of Guides was created in April 1903 by General Order 61, and fell under the purview of the Intelligence Department at Militia Headquarters in Ottawa. However, as the Guides were a service of the Active Militia, and not of the Permanent
Jenkins, Dan
core +1 more source
Molecular Oncology, EarlyView.Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard +5 more
wiley +1 more source
Survivin and Aurora Kinase A control cell fate decisions during mitosis
Molecular Oncology, EarlyView.Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir +2 more
wiley +1 more source