Results 81 to 90 of about 1,410,394 (298)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
, 2015 Following the bloody years of the Civil War, veteran organizations became a breeding ground for nationalism making and memory shaping. Historians, like Caroline Janney and David Blight, have debated what these memories meant for northern veterans.
Bautz, Peter
core
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Thinking of Home: The World War Two Letters of Gerald Koster [PDF]
, 2020 This paper covers the letters of Gerald Koster, who served aboard the USS New Jersey during World War Two. This paper covers his letters from the time of his enlistment in January 1943 through November 1943, and shows how his attitude towards the Navy ...
Uszak, Erica L.
core +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
The Punishment for Apostasy in an Established Islamic Tradition
The Islamic Culture, 2018 The punishment for apostasy is an established Islamic Tradition THe writes,All Muslim j urists agree that the apostate is to be puni.shed. How ever, they differ regarding the punishment itself.
Hafiz Shabbir Ahmed Jamie +1 more
doaj
“The Most Vivifying Influence:” Operation Delta in Preparing the Canadian Corps for the Hundred Days [PDF]
, 2018 Preparation and training for Operation Delta in May and June 1918 provided the Canadian Corps with vital experience for the types of operations conducted during the Hundred Days.
Stewart, William F.
core +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
God Moves in a Mysterious Way : Public Discourse on Providence and the Battle of Gettysburg
, 2002 This study of public reaction to the Battle of Gettysburg in the context of the wider experience of the American Civil War focuses on the view of Providence in history and war.
Andrews, Sarah Marie
core
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source