Results 21 to 30 of about 12,638 (209)

Doping of Graphene Nanoribbons via Functional Group Edge Modification

, 2017
We report on the on-surface synthesis of 7 armchair graphene nanoribbons (7-AGNRs) substituted with nitrile (CN) functional groups. The CN groups are attached to the GNR backbone by modifying the 7-AGNR precursor.
Abadia, Mikel, Barragán, Ana, Brandimarte, Pedro, Carbonell-Sanromà, Eduard, Corso, Martina, Hieulle, Jeremy, Iraola, Mikel, Li, Jingcheng, Pascual, Jose Ignacio, Peña, Diego, Sánchez-Portal, Daniel, Vilas-Varela, Manuel   +11 more
core   +1 more source

Efficient allelic-drive in Drosophila. [PDF]

, 2019
Gene-drive systems developed in several organisms result in super-Mendelian inheritance of transgenic insertions. Here, we generalize this "active genetic" approach to preferentially transmit allelic variants (allelic-drive) resulting from only a single ...
Berni, Mateus, Bier, Ethan, Bobik, Marketta, Gantz, Valentino M, Guichard, Annabel, Haque, Tisha, Kaduskar, Bhagyashree, Klanseck, Carissa, Kushwah, Raja Babu Singh, Xu, Xiang-Ru S   +9 more
core   +3 more sources

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Variational assimilation of Lagrangian data in oceanography [PDF]

, 2006
We consider the assimilation of Lagrangian data into a primitive equations circulation model of the ocean at basin scale. The Lagrangian data are positions of floats drifting at fixed depth.
Assenbaum M Reverdin G, De Mey P, Forget G, Ghil M, Ghil M, Ide K, Jazwinski A H, Le Dimet F X, Lions J L, Lions J L, Madec G, Maëlle Nodet, Ngodock H E, Penenko V V, Reynaud T, Salman H, Talagrand O, Temam R, Thacker W C   +18 more
core   +9 more sources

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Critical phenomena and thermodynamic geometry of charged Gauss-Bonnet AdS black holes

, 2013
In this paper, we study the phase structure and equilibrium state space geometry of charged topological Gauss-Bonnet black holes in $d$-dimensional anti-de Sitter spacetime. Several critical points are obtained in the canonical ensemble, and the critical
H. B. Callen, H. E. Stanley, L. Tisza, R. E. Reichl, Shao-Wen Wei, Yu-Xiao Liu   +5 more
core   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

A search for soft X-ray emission associated with prominent high-velocity-cloud complexes [PDF]

, 1998
We correlate the ROSAT 1/4 keV all-sky survey with the Leiden/Dwingeloo HI survey, looking for soft X-ray signatures of prominent high-velocity-cloud (HVC) complexes.
Burton, W. B., Egger, R., Freyberg, M. J., Hartmann, Dap, Kalberla, P. M. W., Kerp, J., Mebold, U., Pietz, J.   +7 more
core   +2 more sources

Persistence of RNAi-Mediated Knockdown in Drosophila Complicates Mosaic Analysis Yet Enables Highly Sensitive Lineage Tracing. [PDF]

, 2016
RNA interference (RNAi) has emerged as a powerful way of reducing gene function in Drosophila melanogaster tissues. By expressing synthetic short hairpin RNAs (shRNAs) using the Gal4/UAS system, knockdown is efficiently achieved in specific tissues or in
Bosch, Justin A, Hariharan, Iswar K, Sumabat, Taryn M   +2 more
core   +1 more source