Results 31 to 40 of about 12,638 (209)

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Polarized cortical tension drives zebrafish epiboly movements [PDF]

, 2016
The principles underlying the biomechanics of morphogenesis are largely unknown. Epiboly is an essential embryonic event in which three tissues coordinate to direct the expansion of the blastoderm.
Amayra Hernández‐Vega, Concha ML, Daniel Navajas, Enrique Martín‐Blanco, Ignacio Pagonabarraga, Julien Colombelli, María Marsal, Philippe‐Alexandre Pouille, Solnica‐Krezel L, Sébastien Tosi, Tomás Luque, Warga RM, Weliky M, Westerfield M   +13 more
core   +2 more sources

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Innate Immune Reprogramming Mediated by Endogenous Retroelement Dysregulation Drives Multiple Sclerosis Progression

Annals of Clinical and Translational Neurology, EarlyView.
Epigenetic reprogramming in hematopoietic stem and progenitor cells (HSPCs) and downstream myeloid cells, mediated by H3.3 downregulation and endogenous retroelement (ERE) overexpression, contributes to the progression of multiple sclerosis (MS). ABSTRACT Background Skewed myelopoiesis in the bone marrow has been identified as a key driver of multiple ...
Li‐Mei Xiao, Qiu‐Ping Zhao, Run‐Yun Li, Wei Chen, Huan‐Huan Song, Wan‐Jin Chen, Ying Fu   +6 more
wiley   +1 more source

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

The century of the incomplete revolution: searching for general relativistic quantum field theory [PDF]

, 1999
In fundamental physics, this has been the century of quantum mechanics and general relativity. It has also been the century of the long search for a conceptual framework capable of embracing the astonishing features of the world that have been revealed ...
Ashtekar A., Ashtekar A., Ashtekar A., Baez J., Barbero F., Barbero F., Barbieri A., Borissov R., Carlo Rovelli, Connes A., Connes A., Crane L., Foxon T. J., Freidel L., Freidel L., Grott N., Iwasaki J., Krasnov K., Markopoulou F., Pietri R. De, Reisenberger M., Reisenberger M., Rovelli C., Rovelli C., Rovelli C., Rovelli C., Rovelli C., Rovelli C., Rovelli C., Rovelli C., Rovelli C., Rovelli C., Rovelli C., Rovelli C., Rovelli C., Rovelli C., Rovelli C., Rovelli C., Rovelli C., Smolin L., Thiemann T., Turaev V. G., Witten E., Yetter D., Zapata J., Zapata J.   +45 more
core   +2 more sources

Understanding and Optimizing Li Substitution in P2‐Type Sodium Layered Oxides for Sodium‐Ion Batteries

Advanced Functional Materials, EarlyView.
This work explores Li‐substituted P2 layered oxides for Na‐ion batteries by crystallographic and electrochemical studies. The effect of lithium on superstructure orderings, on phase transitions during synthesis and electrochemical cycling and on the interplay of O‐ versus TM‐redox is revealed via various advanced techniques, including semi‐simultaneous 
Mingfeng Xu, Giovanni Gammaitoni, Michael Häfner, Eduardo Villalobos‐Portillo, Carlo Marini, Matteo Bianchini   +5 more
wiley   +1 more source

How wide are European borders? New evidence on the integration effects of monetary unions [PDF]

, 2001
We use consumer price data for 81 European cities (in Germany, Austria, Switzerland, Italy, Spain and Portugal) to study deviations from the law-of-one-price before and during the European Economic and Monetary Union (EMU) by analysing both aggregate and
Beck, Günter W., Weber, Axel A.
core  

Laser‐Induced Graphene from Waste Almond Shells

Advanced Functional Materials, EarlyView.
Almond shells, an abundant agricultural by‐product, are repurposed to create a fully bioderived almond shell/chitosan composite (ASC) degradable in soil. ASC is converted into laser‐induced graphene (LIG) by laser scribing and proposed as a substrate for transient electronics.
Yulia Steksova, Anna Chiara Bressi, Marina Galliani, Attilio Marino, Gianni Ciofani, Eduardo Machado‐Charry, Hilda Gomez Bernal, Alessandra Francini, Luca Sebastiani, Francesco Greco   +9 more
wiley   +1 more source

Single field inflation with modulated potential in light of the Planck and BICEP2

, 2014
The recently released BICEP2 data detected the primordial B-mode polarization in the Cosmic Microwave Background (CMB) map which strongly supports for a large tensor-to-scalar ratio, and thus, is found to be in tension with the Planck experiment with no ...
Cai, Yifu, Li, Mingzhe, Li, Siyu, Qiu, Taotao, Wan, Youping, Zhang, Xinmin   +5 more
core   +1 more source