Results 31 to 40 of about 218,239 (261)

4D Self‐Morphing Culture Substrate for Modulating Cell Differentiation

Advanced Science, 2020
As the most versatile and promising cell source, stem cells have been studied in regenerative medicine for two decades. Currently available culturing techniques utilize a 2D or 3D microenvironment for supporting the growth and proliferation of stem cells.
Shida Miao, Haitao Cui, Timothy Esworthy, Bhushan Mahadik, Se‐jun Lee, Xuan Zhou, Sung Yun Hann, John P. Fisher, Lijie Grace Zhang   +8 more
doaj   +1 more source

4D-Explorer: A visual software for 4D-STEM data processing and image reconstruction

, 2023
44 pages, 23 ...
Hu, Yiming, Gao, Si, Wu, Xiaopeng, Pei, Xudong, Huang, Futao, Mao, Wei, Zhang, Weiyang, Horne, Aidan, Gu, Zhengbin, Wang, Peng   +9 more
openaire   +2 more sources

Small extracellular vesicles derived from four dimensional-culture of mesenchymal stem cells induce alternatively activated macrophages by upregulating IGFBP2/EGFR to attenuate inflammation in the spinal cord injury of rats

Frontiers in Bioengineering and Biotechnology, 2023
Effectively reducing the inflammatory response after spinal cord injury (SCI) is a challenging clinical problem and the subject of active investigation.
Junhua Wang, Qingshuai Wei, Yue Yang, Mingtian Che, Yuanhuan Ma, Lizhi Peng, Haiyang Yu, Huijuan Shi, Guanheng He, Rongjie Wu, Ting Zeng, Xiang Zeng, Wenbin Ma   +12 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Robust design of semi-automated clustering models for 4D-STEM datasets

APL Machine Learning, 2023
Materials discovery and design require characterizing material structures at the nanometer and sub-nanometer scale. Four-Dimensional Scanning Transmission Electron Microscopy (4D-STEM) resolves the crystal structure of materials, but many 4D-STEM data ...
Alexandra Bruefach, Colin Ophus, M. C. Scott   +2 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Investigation of the thermal decomposition of Pu(IV) oxalate: a transmission electron microscopy study

Frontiers in Nuclear Engineering
The degradation of the internal structure of plutonium (IV) oxalate during calcination was investigated with Transmission Electron Microscopy (TEM), electron diffraction, Electron Energy-Loss Spectroscopy (EELS), and 4D Scanning TEM (STEM). TEM lift-outs
Edgar C. Buck, Dallas D. Reilly, Luke E. Sweet, Aaron D. Nicholas, Forrest D. Heller, Gabriel B. Hall, Richard A. Clark, Amanda J. Casella   +7 more
doaj   +1 more source

Overexpression of TaLBD16-4D alters plant architecture and heading date in transgenic wheat

Frontiers in Plant Science, 2022
Lateral organ boundaries domain (LBD) proteins, a class of plant-specific transcription factors with a special domain of lateral organ boundaries (LOB), play essential roles in plant growth and development.
Huifang Wang, Xiaofan Han, Xiaofeng Fu, Xinling Sun, Hailong Chen, Xirui Wei, Shubin Cui, Yiguo Liu, Weiwei Guo, Ximei Li, Jiewen Xing, Yumei Zhang   +11 more
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

4D-PreNet: A Unified Preprocessing Framework for 4D-STEM Data Analysis

CoRR
Automated experimentation with real time data analysis in scanning transmission electron microscopy (STEM) often require end-to-end framework. The four-dimensional scanning transmission electron microscopy (4D-STEM) with high-throughput data acquisition has been constrained by the critical bottleneck results from data preprocessing.
Liu, Mingyu, Mao, Zian, Liu, Zhu, Zhang, Haoran, Guo, Jintao, He, Xiaoya, Huang, Xi, Chu, Shufen, Cheng, Chun, Ding, Jun, Xie, Yujun   +10 more
openaire   +2 more sources