Results 81 to 90 of about 49,029 (222)

Distributed Temporal Coding of Visual Memory Categories in Human Hippocampal Neurons Revealed by an Interpretable Decoding Model

Advanced Science, EarlyView.
This study examines how the human hippocampus encodes visual memory categories. By decoding spiking activity from CA3 and CA1 neurons using an interpretable model, it reveals that category‐specific representations emerge from distributed temporal coding.
Xiwei She, Bryan J. Moore, Brent M. Roeder, George Nune, Brian S. Robinson, Brian Lee, Susan Shaw, Hui Gong, Christianne N. Heck, Gautam Popli, Daniel E. Couture, Adrian W. Laxton, Vasilis Z. Marmarelis, Samuel A. Deadwyler, Charles Liu, Theodore W. Berger, Robert E. Hampson, Dong Song   +17 more
wiley   +1 more source

“Your Women, Let Them Be Silent in the Assemblies” – Religion Matters for Gender Equality (SDG 5)

, 2023
Christine Schliesser
openalex   +1 more source

PIEZO1‐GPX4 Axis Mediates Mechanical Stress‐Induced Vertebral Growth Plate Dysplasia via Ferroptosis Activation

Advanced Science, EarlyView.
Mechanical stress activates PIEZO1 in vertebral growth plate chondrocytes, triggering ferroptosis through direct binding and inhibition of GPX4. This axis promotes lipid peroxidation and pathological ossification, accelerating spinal deformities. Clinical and genetic evidence (Piezo1‐cKO) confirms its role in scoliosis progression.
Fei Chen, Fushuai Peng, Shuqing Chen, Yukun Du, Jianyi Li, Yuanyuan Fan, Zichen Cui, Guanghui Gu, Han Zhang, Zhensong Jiang, Guodong Wang, Xingzhi Jing, Jun Dong, Tao Li, Yongming Xi   +14 more
wiley   +1 more source

TEACHERS’ SELF-EFFICACIOUS BELIEFS APROPOS GENDER EQUALITY PRIORITIZING TO THE UNITED NATIONS SUSTAINABLE DEVELOPMENT GOALS 5

, 2023
Mehboob Ul Hassan, Prof. Dr. Abid Hussain, Muhammad Rizwan, Naila Zaigham   +3 more
openalex   +2 more sources

A Replicable and Generalizable Neuroimaging‐Based Indicator of Pain Sensitivity Across Individuals

Advanced Science, EarlyView.
Humans differ in their sensitivity to pain. With six large and diverse fMRI datasets (total N = 1046), this study finds that such individual differences in pain sensitivity can be tracked by fMRI responses to painful stimuli. A highly generalizable machine learning model is further built to predict pain sensitivity across all datasets and analgesic ...
Li‐Bo Zhang, Xue‐Jing Lu, Hui‐Juan Zhang, Zhao‐Xing Wei, Ya‐Zhuo Kong, Yi‐Heng Tu, Gian Domenico Iannetti, Li Hu   +7 more
wiley   +1 more source

Empowering women in the digital age: can digital financial services fulfil the promise of financial autonomy and gender equality in the attainment of Sustainable Development Goal 5? [PDF]

Mohsin Showkat, Razia Nagina, Usha Nori, Muzamil Ahmad Baba, Mohd Asif Shah   +4 more
openalex   +1 more source

Synergistic Modulation of Microglial Polarization by Acteoside and Ferulic Acid via Dual Targeting of Nrf2 and RORγt to Alleviate Depression‐Associated Neuroinflammation

Advanced Science, EarlyView.
Machine‐learning‐directed phytochemical pair ACT/FA, administered at BDD's orthodox ratio, synergistically modulates microglial polarization via dual Nrf2/RORγt targeting to attenuate neuroinflammation and depressive behaviors. This concentration‐dependent synergism replicates the parent formula's efficacy while providing a mechanistic basis for ...
Dongjing Guo, Qiancheng Mao, Xinyu Fang, Liuxuan Huang, Haoquan Tian, Wenguang Yang, Feiyue Zhou, Ke Ma   +7 more
wiley   +1 more source

Mesenchymal Stromal Cells Play an Analgesic Role Through a Npy2r Sensory Neuron‐Mediated Lung‐to‐Brain Axis

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSC) are considered a promising alternative for neuropathic pain (NP) treatment, but underlying mechanisms remain elusive. Huang et al. illustrate that a Npy2r sensory neuron‐related lung–brain axis contributes to MSC analgesia.
Jing Huang, Taihe Zhou, Yueming Sun, Yuanchen Ma, Yiwen Deng, Keyu Chen, Ruijie Li, Yuan Qiu, Tao Wang, Xiaoyong Chen, Li Huang, Lu Zhu, Xueyi Tu, Ying Wang, Zheming Liu, Rouchen Lin, Yunli Tong, Yuantao Li, Heshe Li, Lin Nie, Rui Fang, Jianqi Feng, Xuhong Wei, Xia Feng, Andy Peng Xiang, Xiaoran Zhang   +25 more
wiley   +1 more source

Therapeutic Repair of Sperm Quality Decline Caused by Polytetrafluoroethylene

Advanced Science, EarlyView.
Exposure to PTFE (teflon), a commonly used microplastic in non‐stick cookware, significantly reduces sperm quality in both humans and mice. Specifically, PTFE induces the disruption of sperm cytoskeleton and F‐actin assembly through targeting SKAP2 in haploid spermatid.
Shiming Gan, Shumin Zhou, Jiaming Zhou, Guanghui Zhang, Jingshou Chen, Rui Liu, Kuan Sun, Sisi Li, Wenjing Xiong, Yujiao Wen, Jianzhong Sheng, Yu Zhang, Jingchao Ren, Youjiang Li, Hefeng Huang, Chen Zhang   +15 more
wiley   +1 more source

Translation of a Human‐Based Malaria‐on‐a‐Chip Phenotypic Disease Model for In Vivo Applications

Advanced Science, EarlyView.
Inoculation of the Malaria‐on‐a‐Chip model with human erythrocytes infected with Plasmodium falciparum can support the entire intraerythrocytic lifecycle for 7 days in vitro. Utilizing this human‐based, serum‐free model provides an alternative to animal testing by introducing a human‐based, preclinical alternative for antimalarial therapeutic delivery.
Michael J. Rupar, Hannah M. Hanson, Brianna L. Botlick, Narasimhan Sriram, Stephanie Rogers, Justin Zuniga, Zhanhe Liu, Steven J. Trimmer, Joseph M. Ciurca, Christopher J. Long, Christopher W. McAleer, Stephan Schmidt, Paola Favuzza, Philip Lowe, Nathalie Gobeau, James J. Hickman   +15 more
wiley   +1 more source