Results 121 to 130 of about 9,097,931 (359)

Inhibition of acyl‐CoA synthetase long‐chain isozymes decreases multiple myeloma cell proliferation and causes mitochondrial dysfunction

open access: yesMolecular Oncology, EarlyView.
Triacsin C inhibition of the acyl‐CoA synthetase long chain (ACSL) family decreases multiple myeloma cell survival, proliferation, mitochondrial respiration, and membrane potential. Made with Biorender.com. Multiple myeloma (MM) is an incurable cancer of plasma cells with a 5‐year survival rate of 59%.
Connor S. Murphy   +12 more
wiley   +1 more source

Pembangunan CD interaktif pengajaran dan pembelajaran bagi mata pelajaran kemahiran hidup bersepadu tingkatan 2 [PDF]

open access: yes, 2018
Kajian ini dijalankan bertujuan untuk membangun dan membuat penilaian ke atas CD Interaktif melalui penggunaan pendekatan strategi pembelajaran tutorial bagi tajuk Ternakan Ikan Air Tawar. CD Interaktif ini disediakan mengikut sukatan pelajaran bagi mata
Md Omar, Noor Hafiza
core   +1 more source

Orissi e GDS: experiências de ensino, aprendizagem e pesquisa

open access: yesPitágoras 500, 2017
Este artigo discute questões sobre o treinamento do ator, articulando noções de técnicas cotidianas e extra-cotidianas, técnicas do corpo, teatro-dança indiano Orissi e método GDS, com experiências de ensino, aprendizagem e pesquisa em Arte.
Priscilla Duarte, Fernando Mencarelli
doaj   +1 more source

Respiratory complex I‐mediated NAD+ regeneration regulates cancer cell proliferation through the transcriptional and translational control of p21Cip1 expression by SIRT3 and SIRT7

open access: yesMolecular Oncology, EarlyView.
NAD+ regeneration by mitochondrial complex I NADH dehydrogenase is important for cancer cell proliferation. Specifically, NAD+ is necessary for the activities of NAD+‐dependent deacetylases SIRT3 and SIRT7, which suppress the expression of p21Cip1 cyclin‐dependent kinase inhibitor, an antiproliferative molecule, at the translational and transcriptional
Masato Higurashi   +5 more
wiley   +1 more source

Analysis of comprehensive genomic profiling of solid tumors with a novel assay for broad analysis in clinical diagnostics

open access: yesMolecular Oncology, EarlyView.
In molecular cancer diagnostics, comprehensive genomic profiling (CGP) is going to replace the small NGS panels since it provides all clinically relevant somatic variants as well as genomic biomarkers with clinical value. Here, we compared two CGP assays and demonstrate that the choice for diagnostic implementation will depend on the specific ...
Guy Froyen   +17 more
wiley   +1 more source

Um Shakespeare Ítalo-Paulista

open access: yesPitágoras 500, 2014
Este estudo focaliza a relação entre o inconsciente e a sub- jetividade no processo de criação, para experimentá-la em uma ela- boração cênica, a partir da prática meditativa e da narrativa de so- nhos.
Elisabeth Azevedo
doaj   +1 more source

Response to neoadjuvant chemotherapy in early breast cancers is associated with epithelial–mesenchymal transition and tumor‐infiltrating lymphocytes

open access: yesMolecular Oncology, EarlyView.
Epithelial–mesenchymal transition (EMT) and tumor‐infiltrating lymphocytes (TILs) are associated with early breast cancer response to neoadjuvant chemotherapy (NAC). This study evaluated EMT and TIL shifts, with immunofluorescence and RNA sequencing, at diagnosis and in residual tumors as potential biomarkers associated with treatment response.
Françoise Derouane   +16 more
wiley   +1 more source

Portfolio Selection: The Power of Equal Weight [PDF]

open access: yesModels and Reality: A Festschrift for James R. Thompson , pp. 225-236 (2017), 2016
We empirically show the superiority of the equally weighted S\&P 500 portfolio over Sharpe's market capitalization weighted S\&P 500 portfolio. We proceed to consider the MaxMedian rule, a non-proprietary rule designed for the investor who wishes to do his/her own investing on a laptop with the purchase of only 20 stocks.
arxiv  

Multiplex single‐cell profiling of putative cancer stem cell markers ALDH1, SOX9, SOX2, CD44, CD133 and CD15 in endometrial cancer

open access: yesMolecular Oncology, EarlyView.
Cancer stem cells are associated with aggressive disease, but a deep characterization of such markers is lacking in endometrial cancer. This study uses imaging mass cytometry to explore putative cancer stem cell markers in endometrial tumors and corresponding organoid models.
Hilde E. Lien   +7 more
wiley   +1 more source

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