Results 131 to 140 of about 9,097,931 (359)

Justifying the Volatility of S&P 500 Daily Returns [PDF]

arXiv
Over the past 60 years, there has been a gradual increase in the volatility of daily returns for the S&P 500 Index. Hypothetically, suppose that market forces determine daily volatility such that a daily leveraged S&P 500 fund cannot outperform a standard S&P 500 fund in the long run. Then this hypothetical volatility happens to support the increase in
arxiv  

Ein Bericht über 500 Blasensteinoperationen an Erwachsenen männlichen Geschlechts [PDF]

, 1879
Henry S. Thompson
openalex   +1 more source

Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance

Molecular Oncology, EarlyView.
Cellular heterogeneity is a major cause of drug resistance in cancer. Segeren et al. used single‐cell transcriptomics to investigate gene expression events that correlate with sensitivity to the DNA‐damaging drugs gemcitabine and prexasertib. They show that dampened expression of transcription factor FOXM1 and its target genes protected cells against ...
Hendrika A. Segeren, Kathryn A. Wierenga, Frank M. Riemers, Elsbeth A. van Liere, Bart Westendorp   +4 more
wiley   +1 more source

Crime and Punishment in the "American Dream" [PDF]

We observe that countries where belief in the "American dream" (i.e., effort pays) prevails also set harsher punishment for criminals. We know from previous work that beliefs are also correlated with several features of the economic system (taxation ...
Di Tella, Rafael, Dubra, Juan
core   +1 more source

Não ande por aí nua em pelo

Pitágoras 500, 2013
Em As rãs, de Aristófanes, somos levados pelo comediógrafo grego às portas do Hades na companhia do deus Diôniso (disfarçado de Hércules) e de seu servo, Xântias. Mal roga para que se abra o portão do Ínfero, Diôniso é recebido aos socavões e impropérios
Georges Feydeau, Marcos Barbosa
doaj  

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

Molecular Oncology, EarlyView.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam, Megan E. Roche, Zhao Lin, Diana Whitaker‐Menezes, Victor Diaz‐Barros, Eurico Serrano, Maria Paula Martinez Cantarin, Nancy J. Philp, Atrayee Basu Mallick, Ubaldo Martinez‐Outschoorn   +9 more
wiley   +1 more source

Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM

Molecular Oncology, EarlyView.
CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak, Żaneta Zarębska, Marcin P. Sajek, Adriana Grabowska, Alessia Buratin, Paweł Głodowicz, Julia O. Misiorek, Konrad Kuczyński, Stefania Bortoluzzi, Marek Żywicki, Jan G. Kosiński, Agnieszka Rybak‐Wolf, Rafał Piestrzeniewicz, Anna M. Barciszewska, Katarzyna Rolle   +14 more
wiley   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Africanos: 500 años después

Chasqui, 1991
En la actualidad, en las Américas, existen 100 millones de negros descendientes. En los siglos XV y XIX llegaron al Nuevo mundo 30 millones de esclavos que se constituyeron en la mayor migración forzada en toda la historia de la humanidad. Se presenta la cronología de la incomunicación, la comunicación horizontal subterránea, los afroamericanos y los ...
openaire   +3 more sources

An Inquiry into the Primary Seat of Infection in 500 Cases of Death from Tuberculosis [PDF]

, 1904
J O Symes, Thomas Fisher
openalex   +1 more source