Results 261 to 270 of about 9,896,464 (337)

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

UHPLC/MS Profile and Antimalarial Potency of <i>Enantia chlorantha</i> Oliv. (Annonaceae) Stem Bark Aqueous Extract. [PDF]

Adv Pharmacol Pharm Sci
Messi Betene AN, Gounoue Kamkumo R, Tsouh Fokou PV, Ngueguim Tsofack F, Mbock MA, Madiesse Kemgne EA, Ngako A, Ngwem Tenlep LS, Tsakem Nangap MJ, Fokou R, Dize D, Owona P, Tchatat Tali MB, Fekam Boyom F, Dimo T.   +14 more
europepmc   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Analysis of refractive index sensing properties of independently and arbitrarily tunable multiplexed compound supercell gratings. [PDF]

Sci Rep
Abudula A, Fang Y, Tuxun H, Tuersun P.
europepmc   +1 more source

Impact of Interest Rates on S&P 500 Stock Returns : A Comparative Analysis of Value and Growth Stocks

Sigfrid, Ivan, Rozkov, Aleksei
openalex   +1 more source

Stability of 500 kA Cells with Graphitized Cathodes and Copper-Insert Collector Bars During Early Operation

Yong Shi, Dejiang Ni, Qianwei Hu
openalex   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Recurrent Neural Networks with Integrated Gradients Explanation for Predicting the Hysteresis Behavior of Shape Memory Alloys. [PDF]

Sensors (Basel)
Tymoshchuk D, Yasniy O, Didych I, Maruschak P, Lutsyk N.   +4 more
europepmc   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Preparation of Biochar from Papermaking Sludge and Its Adsorption Characteristics for Tetracycline. [PDF]

Toxics
Niu J, Fan S, Wu Z.
europepmc   +1 more source