Results 331 to 340 of about 1,768,342 (381)

Validated HPLC-MS/MS method for quantitation of AMG 510, a KRAS G12C inhibitor in a small volume of mouse plasma and its application to a pharmacokinetic study in mice.

Biomedical chromotography, 2020
AMG 510 is the first-in-class KRASG12C inhibitor, currently entering into Phase-2 clinical trials as an orphan drug to treat non-small cell lung cancer patients.
N. Madhyastha, Swapan Kumar Samantha, Sreekanth Dittakavi, Meenu Markose, S. Mallurwar, M. Zainuddin, R. Mullangi   +6 more
semanticscholar   +1 more source

510. Angraecum Praestans

Curtis's Botanical Magazine, 2004
Summary.  The history, taxonomy, habitat and cultivation of Angraecum praestans Schltr. from Madagascar are discussed. A description is provided.
openaire   +2 more sources

microRNA‐510‐5p promotes thyroid cancer cell proliferation, migration, and invasion through suppressing SNHG15

Journal of Cellular Biochemistry, 2019
SNHG15 has been suggested to be correlated with clinical progression and prognosis, and function as tumor suppressive long noncoding RNA in thyroid cancer at our previous study.
Yongcun Liu, Junli Li, M. Li, Feng Li, Y. Shao, Liping Wu   +5 more
semanticscholar   +1 more source

Metabolic Engineering of Corynebacterium glutamicum for the High-Level Production of Cadaverine That Can Be Used for the Synthesis of Biopolyamide 510

, 2018
Fermentative production of cadaverine from renewable resources may support a sustainable biorefinery process to produce carbon-neutral nylons such as biopolyamide 510 (PA510).
Hee Taek Kim, Kei-Anne Baritugo, Y. Oh, S. Hyun, Tae Uk Khang, K. Kang, S. Jung, B. Song, Kyungmoon Park, Il-Kwon Kim, M. Lee, Y. Kam, Y. Hwang, Si Jae Park, J. Joo   +14 more
semanticscholar   +1 more source

Abstract 4484: Discovery and in vitro characterization of AMG 510–a potent and selective covalent small-molecule inhibitor of KRASG12C

Experimental and Molecular Therapeutics, 2019
Activating mutations in RAS represent the most common oncogenic driver mutation in cancer. The single amino acid substitution of cysteine for glycine at position 12 (KRASG12C) is frequently found in solid malignancies, particularly in lung adenocarcinoma
A. Y. Saiki, Kevin Gaida, K. Rex, Pragathi Achanta, T. S. Miguel, Neelima Koppada, Dhanashri Bagal, B. Lanman, Robert S. Foti, J. McCarter, Laurie P. Volak, J. Canon, V. Cee, J. Lipford   +13 more
semanticscholar   +1 more source

Synthesis and properties of nylon 6/66/510 used as hot melt adhesives for metal plate with low-surface-energy coating

Journal of Adhesion Science and Technology, 2019
In this work, nylon 6/66 and nylon 6/66/510 containing 5 ∼ 20 mol % nylon-510 were synthesized to be used as hot melt adhesive for metal plate with low-surface-energy coating.
Weilan Xue, Zegang Zong, Lei Zhou, Zuoxiang Zeng   +3 more
semanticscholar   +1 more source

Uteroplacental diastolic notching in 510 uneventful pregnancies

jpme, 1992
In a collective of 510 patients with uneventful pregnancies and deliveries the rate of waveform notching in the uteroplacental flow velocity pattern was examined. Notching appeared to be significantly more frequent in the uterine than arcuate artery. It was unilateral and mainly affected placenta-contralateral sites.
Dieter Grab, Karl Sterzik, A. Wolf, Wolfgang Hütter, Rainer Terinde   +4 more
openaire   +3 more sources

High expression of miR‐510 was associated with CGG expansion located at upstream of FMR1 into full mutation

Journal of Cellular Biochemistry, 2018
MicroRNAs (miRNAs) have been found to play an important role in the regulation of gene expression in eukaryotic organisms at the posttranscriptional level. More than half of miRNA genes have been recognized to be located in different fragile sites. Among
Z. Fazeli, S. Ghaderian, H. Najmabadi, M. Omrani   +3 more
semanticscholar   +1 more source

What Is a 510(k) and a PMA?

1996
Prior to marketing a device in the United States, manufacturers or initial distributors of imported devices must obtain Food and Drug Administration (FDA) marketing clearance. There are two routes to the market: premarket notification [510(k)] and premarket approval(PMA).
openaire   +2 more sources

Insights into Hägg Iron-Carbide-Catalyzed Fischer–Tropsch Synthesis: Suppression of CH4 Formation and Enhancement of C–C Coupling on χ-Fe5C2 (510)

, 2015
Probing the product selectivity of Fischer–Tropsch catalysts is of prime scientific and industrial importance—with the aim to upgrade products and meet various end-use applications.
T. Pham, Yanying Qi, Jia Yang, Xuezhi Duan, G. Qian, Xinggui Zhou, De Chen, W. Yuan   +7 more
semanticscholar   +1 more source