Results 81 to 90 of about 3,295 (118)
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Cancer Research, 2023
Abstract Introduction: While the prognostic value of immune system biomarkers has been well explored, role of cancer associated macrophages in bladder cancer(BC) is unclear due to lack of consistent results, coupled with tissue nonspecific transcriptomic signature.
Laura Bukavina +12 more
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Abstract Introduction: While the prognostic value of immune system biomarkers has been well explored, role of cancer associated macrophages in bladder cancer(BC) is unclear due to lack of consistent results, coupled with tissue nonspecific transcriptomic signature.
Laura Bukavina +12 more
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Cancer Research, 2022
Abstract The promise of precision medicine in oncology is to identify the ideal treatment for each patient, eliminating failed treatment cycles and reducing treatment burdens on patients and payors. While gene sequencing can predict effective treatment options in some cases, studies have estimated that only 10-15% of cancer patients are ...
Jonathan Scolnick +4 more
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Abstract The promise of precision medicine in oncology is to identify the ideal treatment for each patient, eliminating failed treatment cycles and reducing treatment burdens on patients and payors. While gene sequencing can predict effective treatment options in some cases, studies have estimated that only 10-15% of cancer patients are ...
Jonathan Scolnick +4 more
openaire +1 more source
Cancer Research, 2010
Abstract Aggressive metastatic neuroblastoma confers a poor clinical prognosis. Stathmin is a microtubule destabilizing protein highly expressed in advanced stage (metastatic) neuroblastoma (1) that promotes metastasis of non-neuronal cancers (2). However, stathmin's role in neuroblastoma metastasis is unclear.
Frances L. Byrne +2 more
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Abstract Aggressive metastatic neuroblastoma confers a poor clinical prognosis. Stathmin is a microtubule destabilizing protein highly expressed in advanced stage (metastatic) neuroblastoma (1) that promotes metastasis of non-neuronal cancers (2). However, stathmin's role in neuroblastoma metastasis is unclear.
Frances L. Byrne +2 more
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Cancer Research, 2015
Abstract There has been longstanding interest in the relationship between the immune system and malignant melanoma, the deadliest form of skin cancer. Melanoma has been the tumor of choice for the evaluation of a wide variety of therapeutic approaches that rely on stimulation of the immune system to combat cancer.
Katrina M. Meeth +2 more
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Abstract There has been longstanding interest in the relationship between the immune system and malignant melanoma, the deadliest form of skin cancer. Melanoma has been the tumor of choice for the evaluation of a wide variety of therapeutic approaches that rely on stimulation of the immune system to combat cancer.
Katrina M. Meeth +2 more
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Abstract 5141: Determinants of metastatic competence in breast carcinoma: a role for immune cells
Cancer Research, 2016Abstract Dynamic interactions between cancer cells and their surrounding microenvironment influence tumor survival, growth and metastasis. The tumor microenvironment harbors a complex variety of cells including T lymphocytes and macrophages that produce a host of cytokines, chemokines, growth factors or interleukins, all of which ...
Robiya Joseph +3 more
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Cancer Research, 2014
Abstract HDAC (histone deacetylase) enzymes are highly expressed in cancer cells and HDAC inhibitors have shown promise in clinical trials for certain patients in multiple types of cancer. In this context, the ability of the SW13 human adrenal adenocarcinoma line to switch between two well-established subtypes in response to HDAC ...
Jessica M. Lam +3 more
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Abstract HDAC (histone deacetylase) enzymes are highly expressed in cancer cells and HDAC inhibitors have shown promise in clinical trials for certain patients in multiple types of cancer. In this context, the ability of the SW13 human adrenal adenocarcinoma line to switch between two well-established subtypes in response to HDAC ...
Jessica M. Lam +3 more
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Cancer Research, 2012
Abstract Most proliferating and tumor cells generate the energy required to support rapid cell division by aerobic glycolysis instead of oxidative phosphorylation (Warburg effect). By extension, in order to meet the increased requirements of proliferation, they often display essential changes in energy metabolism and nutrient uptake ...
Valeria Gabriela Antico Arciuch +1 more
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Abstract Most proliferating and tumor cells generate the energy required to support rapid cell division by aerobic glycolysis instead of oxidative phosphorylation (Warburg effect). By extension, in order to meet the increased requirements of proliferation, they often display essential changes in energy metabolism and nutrient uptake ...
Valeria Gabriela Antico Arciuch +1 more
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Cancer Research, 2017
Abstract Antibody-drug conjugates (ADCs) have been FDA approved for targeted delivery of chemotherapy to a small subset of cancers. However, there are significant limitations in their clinical utility in the majority of cancers: despite hundreds of clinical trials, there are only two FDA approved drugs currently on the market.
Theo L. Sottero +3 more
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Abstract Antibody-drug conjugates (ADCs) have been FDA approved for targeted delivery of chemotherapy to a small subset of cancers. However, there are significant limitations in their clinical utility in the majority of cancers: despite hundreds of clinical trials, there are only two FDA approved drugs currently on the market.
Theo L. Sottero +3 more
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Circulation, 2009
Background: Endothelial dysfunction and platelet activation are part of the cardiovascular phenotype of severe congestive heart failure(CHF). An association between reduced endothelium-dependent NO-bioavailability and platelet activation has been described in experimental CHF.
Andreas Schaefer +2 more
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Background: Endothelial dysfunction and platelet activation are part of the cardiovascular phenotype of severe congestive heart failure(CHF). An association between reduced endothelium-dependent NO-bioavailability and platelet activation has been described in experimental CHF.
Andreas Schaefer +2 more
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Vaccine, 2014
Ludwig Boltzmann Institute for Health Technology Assessment, Garnisongasse 7/20, 1090 Vienna, Austria Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway Institute of Microparasite Epidemiology, Imperial College, St. Mary’s Campus, London, United Kingdom Norwegian Knowledge Centre for the Health Service, Oslo, Norway UMIT – University
Ingrid Zechmeister +4 more
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Ludwig Boltzmann Institute for Health Technology Assessment, Garnisongasse 7/20, 1090 Vienna, Austria Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway Institute of Microparasite Epidemiology, Imperial College, St. Mary’s Campus, London, United Kingdom Norwegian Knowledge Centre for the Health Service, Oslo, Norway UMIT – University
Ingrid Zechmeister +4 more
openaire +1 more source