Results 11 to 20 of about 183,356 (307)

A Population Pharmacokinetic and Pharmacodynamic Model of CKD-519 [PDF]

open access: yesPharmaceutics, 2020
CKD-519 is a selective and potent cholesteryl ester transfer protein (CETP) inhibitor that is being developed for dyslipidemia. Even though CKD-519 has shown potent CETP inhibition, the exposure of CKD-519 was highly varied, depending on food and dose ...
Choon Ok Kim   +2 more
exaly   +5 more sources

Pharmacokinetics, pharmacodynamics and safety of CKD-519, a CETP inhibitor, in healthy subjects

open access: yesDrug Design, Development and Therapy, 2016
Choon Ok Kim,1 Eun Sil Oh,2 Chungam Choi,1 Yeonjoo Kim,3 Sera Lee,4 Semi Kim,4 Min Soo Park1,5 1Department of Clinical Pharmacology, Severance Hospital, Yonsei University College of Medicine, Seoul, 2Department of Pharmaceutical Medicines and ...
Kim CO   +6 more
doaj   +1 more source

MicroRNAs miR-16 and miR-519 control meningioma cell proliferation via overlapping transcriptomic programs shared with the RNA-binding protein HuR

open access: yesFrontiers in Oncology, 2023
IntroductionMeningiomas are the most common type of primary central nervous system tumors. In about 80% cases, these tumors are benign and grow very slowly, but the remainder 20% can unlock higher proliferation rates and become malignant.
Rémi Houlgatte   +2 more
exaly   +3 more sources

Single nucleotide variations in the ANXA5 promoter regulated piglet weight in the Min pig [PDF]

open access: yesFrontiers in Veterinary Science
ANXA5 is a pleiotropic candidate gene, however its effect on piglet production trait remains unclear. In this study, a novel SNP: g.-519 A > G was identified in ANXA5 promoter. In Min pigs, association analysis showed the birth weight of AA animals at
Mingyang Han   +12 more
doaj   +2 more sources

Early marketable yield and better berry skin color of ‘Redglobe’ grapevines cultivar grown under warm climate by application of Sulis® [PDF]

open access: yesJournal of Plant Production, 2021
Coloration of red grapes under high temperature and narrow day/night temperature range conditions is a great challenge. The aim of the investigation was to test the effect of Sulis® fertilizer which has recently commercially released in Egypt on the ...
A. Mohamed, Heba Sayed
doaj   +1 more source

A comparison of surgical efficacy between a 1.8-mm microincision and 3.2-mm and 5.5-mm incisions for phacoemulsification [PDF]

open access: yesInternational Journal of Ophthalmology, 2018
Phacoemulsification is a commonly used surgical method in cataract surgery. This paper observes and compares the surgical efficacy of three incisions of different length for phacoemulsification to identify the optimal method for cataract surgery.
E Song   +8 more
doaj   +1 more source

Condition and Performance Assessment of Irrigation Infrastructure at Agri-Parks in Gauteng Province, South Africa

open access: yesApplied Sciences, 2023
South African agriculture accounts for 62% of the national water demand. Almost 45% of the water is wasted. Therefore, irrigation systems need to improve their water-use efficiency (WUE). However, the WUE of smallholder irrigation schemes in the country,
Macdex Mutema   +2 more
doaj   +1 more source

Parameter Matching Method of a Battery-Supercapacitor Hybrid Energy Storage System for Electric Vehicles

open access: yesWorld Electric Vehicle Journal, 2021
To satisfy the high-rate power demand fluctuations in the complicated driving cycle, electric vehicle (EV) energy storage systems should have both high power density and high energy density.
Fengchen Liu, Chun Wang, Yunrong Luo
doaj   +1 more source

Inverse modeling of Texas NOx emissions using space-based and ground-based NO2 observations [PDF]

open access: yesAtmospheric Chemistry and Physics, 2013
Inverse modeling of nitrogen oxide (NOx) emissions using satellite-based NO2 observations has become more prevalent in recent years, but has rarely been applied to regulatory modeling at regional scales.
W. Tang   +4 more
doaj   +1 more source

Hypoxia-Induced Sarcoplasmic Reticulum Ca2+ Leak Is Reversed by Ryanodine Receptor Stabilizer JTV-519 in HL-1 Cardiomyocytes

open access: yesAnatolian Journal of Cardiology, 2022
Background: To assess whether hypoxia, as can be found in obstructive sleep apnea syndrome, is causally associated with the development of heart failure through a direct effect on calcium leakage from the sarcoplasmic reticulum.
Minh Duc Trinh   +6 more
doaj   +1 more source

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