Results 241 to 250 of about 1,815,334 (333)

Homoisoflavanone Delays Colorectal Cancer Progression via DNA Damage‐Induced Mitochondrial Apoptosis and Parthanatos‐Like Cell Death

Advanced Science, EarlyView.
Homoisoflavanone (HIF), a bioactive compound isolated from Polygonatum kingianum, selectively suppresses colorectal cancer progression by inducing DNA damage‐mediated mitochondrial apoptosis and parthanatos‐like cell death. HIF triggers mitochondrial dysfunction, including depolarized membrane potential, elevated ROS, and ATP depletion, while impairing
Hongjie Fan, Huzi Zhao, Pei Zhang, Pengfei Yu, Yunfei Ji, Gang Chen, Hongli Jin, Yanfang Liu, Jin Liu, Zhe‐Sheng Chen, Aiping Lyu, Xinmiao Liang, Yang Chen   +12 more
wiley   +1 more source

Miniaturized widefield microscope for high speed in vivo voltage imaging. [PDF]

Biomed Opt Express
Saladrigas CA, Speed F, Teel A, Zohrabi M, Miscles EJ, Futia GL, Baker LV, Zhang Y, Kymissis I, Bright VM, Welle CG, Restrepo D, Gopinath JT, Gibson EA.   +13 more
europepmc   +1 more source

Pers Kralı Büyük Kyros’un (MÖ 559-530) Orta Asya Seferleri ve Ölümü

, 2017
Eray Karaketir
openalex   +1 more source

Dipiperazine‐Phenyl Derivatives Based on Convergent Molecular Platforms Can Reverse Multidrug Resistance in Gram‐Negative Bacteria by Inhibiting Efflux and Permeabilizing Cell Membranes

Advanced Science, EarlyView.
By integrating a convergent molecular platform strategy, this study designed a novel dual‐target C5 to combat multidrug‐resistant Gram‐negative bacteria. C5 synergistically enhances antibiotic efficacy by inhibiting efflux pumps and increasing bacterial membrane permeability.
Jiale Dong, Ting Guo, Yi Huang, Yangchun Ma, Weijin Chen, Jie Xue, Jun Jiang, Enhui Dong, Yue Kong, Hang Ding, Wenlong Zhang, Shutao Ma   +11 more
wiley   +1 more source

Uncommon findings of primary diffuse large B-cell lymphoma of the central nervous system: Multifocal simultaneous hemorrhage. [PDF]

Radiol Case Rep
Takahashi R, Koyasu S, Sawada T, Umeda T, Sugiyama J, Ishimori T.   +5 more
europepmc   +1 more source

Flipping the Switch: MeCP2‐Mediated Lactylation Rewires Microglial Metabolism and Inflammation via the HK2/mTOR Axis in Poststroke Neuroinflammation

Advanced Science, EarlyView.
Stroke‐induced lactate accumulation promotes p300‐mediated lactylation of methyl‐CpG binding protein 2 (MeCP2) at lysine 210, which reprograms microglial metabolism toward glycolysis and activates the hexokinase 2 (HK2)/mTOR axis. This cascade promotes proinflammatory responses and impairs neurofunctional outcomes.
Zengyu Zhang, Shanshan Huang, Yong Wang, Zhiwen Jiang, Zhuohang Liu, Chenran Wang, Rong Ji, Yiwen Yuan, Xueyu Mao, Kaicheng Yang, Huicong Niu, Yanqin Gao, Jing Zhao   +12 more
wiley   +1 more source

Epidemiology and clinical profiles of neonates with <i>Mycoplasma pneumoniae</i> infection during the post-COVID-19 era in Chengdu. [PDF]

Transl Pediatr
Kang X, Gong Y, Zhong Y, Gao S.
europepmc   +1 more source

530 Numerical Simulation on Anti-Squat of a Racing Motorcycle with Four-Link Rear Suspension

, 2006
Kouta NAKAO, Hiroshi Tokunaga
openalex   +1 more source

Combined Photothermal and mTOR‐Targeted Therapy Overcomes Immune Evasion and Enhances Checkpoint Blockade Efficacy in Metastatic Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study reveals that photothermal therapy, while inducing immunogenic cell death in triple‐negative breast cancer, paradoxically activates the oncogenic mTOR pathway to drive immune evasion. To counter this, a smart nanocomposite is engineered to co‐deliver localized hyperthermia and mTOR inhibition.
Yujie Zhao, Jing Yu, Xin Wang, Xu Liu, Fengli Zuo, Tianyue Xu, Leyi Tang, Ling Xiong, Li Li, Huifang Li, Xiaoting Chen, Guang Yang, Jing Jing, Xiaowei Liu   +13 more
wiley   +1 more source

Correction: Green synthesis of gum Arabic-activated magnetite-nickel nanoparticles for selective removal of Cd(ii) and Cu(ii) from complex aqueous systems. [PDF]

RSC Adv
Taha EH, El-Zahhar AA, Alghamdi MM, Masoud AM, Kamel MF, Taha MH.   +5 more
europepmc   +1 more source