Results 291 to 300 of about 1,686,057 (374)

Structural Characterization and AI‐Enhanced Modeling of a Broadly Neutralizing Camelid Antibody Against SARS‐CoV‐2 Variants

Advanced Therapeutics, EarlyView.
This study characterizes a camelid antibody (B10) with potent neutralizing activity against SARS‐CoV‐2 Wildtype and Omicron variants. Through binding assays, epitope mapping, pseudovirus neutralization, and AI‐driven modeling, the antibody is shown to target conserved RBD regions in a closed Spike conformation.
Katja Hanack, Urszula Orzeł, Anja Schlör, Sourabh Mehta, Anandi Krishnan, Slawomir Filipek, Rushika Patel, Madhvi Joshi, Markus Hoffmann, Stefan Pöhlmann, Chaitanya Joshi, Dorian Liepmann, Ramasamy Paulmurugan, Venkatesan Renugopalakrishnan   +13 more
wiley   +1 more source

Investigation and analysis of hand characteristics of Chinese Han youth in Shandong province: A cross-sectional study. [PDF]

Medicine (Baltimore)
Li G, Sun Z, Li Z, Cheng H, Liu M.
europepmc   +1 more source

Design of CsSnBr3/Ga2O3 Hybrid Photodetectors for High UV Selectivity and Bifacial Usage

Advanced Theory and Simulations, EarlyView.
A numerical study investigates a lead‐free CsSnBr3/Ga2O3 p–n heterojunction photodetector, analyzing its electrical and optoelectronic performance. High illumination‐to‐dark current ratios and rectification are achieved. The device operates in self‐powered, bifacial, solar‐blind, and UV–Vis modes with strong responsivity and detectivity.
Tarak Hidouri, Selma Rabhi, Hicham Bencherif, Roberto Fornari   +3 more
wiley   +1 more source

Melatonin Modulates Glucose Metabolism Reprogramming via Targeting G6PD to Alleviate Lead‐Induced Hepatocytes Pyroptosis in Common Carp (Cyprinus carpio L.)

Advanced Science, EarlyView.
This study reveals that Lead reprograms glucose metabolism to enhance H3K18la, driving DRP1‐dependent mitochondrial DNA leakage and cGAS‐STING‐mediated pyroptosis. Melatonin targets G6PD to suppress glycolysis‐driven H3K18la and restore mitochondrial homeostasis, thereby alleviating Lead‐induced liver injury in common carp through disruption of the ...
Zhiying Miao, Xiaofeng Ji, Lai Wei, Zhiruo Miao, Shiwen Xu   +4 more
wiley   +1 more source

Reply to the Comments on "A Cross-sectional Trait Versus State Biomarker Analysis of Inflammatory Cytokines and miRNAs in Patients with Major Depressive Disorder". [PDF]

Indian J Psychol Med
Rockson C, Girish C, Natarajan H, Menon V.   +3 more
europepmc   +1 more source

Subventricular Zone‐on‐a‐Chip: A Model to Study Neurogenesis Disruption in Neonatal Intraventricular Hemorrhage

Advanced Science, EarlyView.
A human subventricular zone‐on‐a‐chip is developed to model intraventricular hemorrhage (IVH) in preterm infants. This platform enables the study of inflammation‐driven neurogenic disruption. Exposure to hemorrhagic cerebrospinal fluid and red blood cell lysate activated inflammatory pathways, with IL1B emerging as a key mediator.
Laura Nicoleti Zamproni, Begüm Gökçe, Magnus Gram, Coco Holliday, Aylin Sendemir, Marimélia Aparecida Porcionatto, Anna Herland   +6 more
wiley   +1 more source

Fast-response self-powered double-heterojunction n-ZnO/p-ZnTe/n-Si photodetector. [PDF]

Nanoscale Adv
Salih EY, Eisa MH, Mohammed MKA, Ramizy A, Aldaghri O, Ismail RA, Ibnaouf KH.   +6 more
europepmc   +1 more source

A Comprehensive Lateral Flow Strip Assay for On‐Site mRNA Vaccine Quality Control in Decentralized Manufacturing

Advanced Science, EarlyView.
A rapid, portable lateral flow strip assay for on‐site mRNA quality control is developed, enabling sequence‐independent analysis of 5' capping, integrity, and LNPs encapsulation efficiency. This cost‐effective method offers real‐time stability monitoring, reduced sample requirements, and comparable accuracy to standard techniques, enhancing ...
Dengwang Luo, Ziwei Zhang, Jing Guo, Jieli Zhang, Arong Huang, Qinghao Cao, Jiangnan Zheng, Yingjin Yuan, Daming Wang, Yuhong Cao   +9 more
wiley   +1 more source

Probing mitochondrial peroxynitrite biogenesis by a N-morpholinoarylimine-based iridium(III) complex in drug-induced liver cells. [PDF]

Redox Biol
Kong L, Wang L, Zhang Z, Ye L, Shiu-Hin Chan D, Wong CY, Wang J, Leung CH, Wang W.   +8 more
europepmc   +1 more source

Polyadenylation Complex CFII Recognizes Downstream Cis‐element for Pre‐mRNA Polyadenylation Through Interaction with an RNA‐Binding Protein in Arabidopsis

Advanced Science, EarlyView.
This study investigates the cis‐element in pre‐mRNA recognized by the polyadenylation CFII complex. It elucidates how the CFII complex recognizes the consensus cis‐element downstream of the poly(A) site for pre‐mRNA alternative polyadenylation. This comprehensive research provides novel insights into the interaction between 3′ end processing complexes ...
Ying Cao, Ying Guo, Zhibo Yu, Huajian Nie, Jing Yang, Dingfu Qiu, Qiyu Li, Xu Xin, Chang Cheng, Yan Li, Xudong Shang, Yuling Jiao, Qingshun Quinn Li, Ligeng Ma   +13 more
wiley   +1 more source