Results 141 to 150 of about 63,432 (241)

Biological properties of potent inhibitors of class I phosphatidylinositide 3-kinases: from PI-103 through PI-540, PI-620 to the oral agent GDC-0941

Molecular Cancer Therapeutics, 2009
F. Raynaud, S. Eccles, Sonal Patel, Sonia Alix, G. Box, Irina S. Chuckowree, A. Folkes, S. Gowan, A. K. de Haven Brandon, F. Di Stefano, A. Hayes, Alan T. Henley, Letitia Lensun, Giles Pergl-Wilson, Anthony Robson, N. Saghir, A. Zhyvoloup, E. McDonald, P. Sheldrake, S. Shuttleworth, M. Valenti, N. Wan, P. Clarke, P. Workman   +23 more
semanticscholar   +1 more source

Isoquercitrin Alleviates Diabetic Nephropathy by Inhibiting STAT3 Phosphorylation and Dimerization

Advanced Science, EarlyView.
This study identified a natural compound, isoquercitrin, which significantly alleviated kidney inflammation and fibrosis by inhibiting STAT3 activity. Isoquercitrin forms a strong, noncovalent bond that directly binds to STAT3. Isoquercitrin binds to the pY+1 pocket of the SH2 domain of STAT3 via hydrogen bonding with Ser668, Gln635, and Gln633 ...
Chen Xuan, Donghui Chen, Shuangna Zhang, Chaofan Li, Qingyun Fang, Dinghua Chen, Jiabao Liu, Xin Jiang, Yingjie Zhang, Wanjun Shen, Guangyan Cai, Xiangmei Chen, Ping Li   +12 more
wiley   +1 more source

Simultaneous Harvesting of Bipolar Plasmonic Hot Carriers for Boosting Photoconductivity in Ag Nanoprism‐Coupled Lateral Si p–n Junction

Advanced Science, EarlyView.
This study demonstrates a plasmonic hot carrier device capable of extracting both types of hot carriers simultaneously using a lateral Si p–n junction diode coupled to Ag nanoprisms. The experimental and numerical results jointly reveal precise control of the generation and injection of plasmonic hot carriers, stemming from differing injection ...
Yujin Park, Jihyang Park, Yeonghoon Jin, Yujin Roh, Hyunhwa Lee, Kyoungsik Yu, Moonsang Lee, Jeong Young Park   +7 more
wiley   +1 more source

A microRNA expression signature of human solid tumors defines cancer gene targets

Proceedings of the National Academy of Sciences of the United States of America, 2006
S. Volinia, G. Calin, Chang-gong Liu, S. Ambs, A. Cimmino, F. Petrocca, R. Visone, M. Iorio, C. Roldo, M. Ferracin, R. Prueitt, N. Yanaihara, G. Lanza, A. Scarpa, A. Vecchione, M. Negrini, C. Harris, C. Croce   +17 more
semanticscholar   +1 more source

Engineering the Immune Response to Biomaterials

Advanced Science, EarlyView.
This paper reviews immune responses to biomaterials, stages of evolution in relation to managing these responses ranging from preventing to modulating them. It also discusses state‐of‐the‐art strategies to modulate these responses and modes of their delivery.
Abolfazl Salehi Moghaddam, Mehran Bahrami, Einollah Sarikhani, Rumeysa Tutar, Yavuz Nuri Ertas, Faleh Tamimi, Ali Hedayatnia, Clotilde Jugie, Houman Savoji, Asma Talib Qureshi, Muhammad Rizwan, Chima V. Maduka, Nureddin Ashammakhi   +12 more
wiley   +1 more source

Inhibiting the Histone Demethylase Kdm4a Restrains Cardiac Fibrosis After Myocardial Infarction by Promoting Autophagy in Premature Senescent Fibroblasts

Advanced Science, EarlyView.
Kdm4a downregulation restrains excessive cardiac interstitial fibrosis and remodeling by depressing the premature senescence of fibroblasts in the advanced stage after MI but does not affect early ventricular rupture. It verified that Kdm4a downregulation promotes autophagy in premature senescent fibroblasts by increasing the H3K9m3 modification of the
Ming Jin, Chuling Li, Zhaoyi Wu, Zhenquan Tang, Jingfang Xie, Guoquan Wei, Zhiwen Yang, Senlin Huang, Yijin Chen, Xinzhong Li, Yanmei Chen, Wangjun Liao, Yulin Liao, Guojun Chen, Hao Zheng, Jianping Bin   +15 more
wiley   +1 more source

Time‐Resolved Dynamics of Laser Ablation in Liquid with Gas‐Evolving Additives: Toward Molding the Atomic Structure of Nonequilibrium Nanoalloys

Advanced Science, EarlyView.
Laser ablation in liquid still holds great potential for the synthesis of multicomponent non‐equilibrium nanomaterials. Here, time‐resolved experiments reveal that gas‐evolving additives both have chemical effects and reduce shockwave pressure. This approach offers a strategy to control the atomic structure of the nanoalloys, easily switching from ...
Vito Coviello, Catherine Reffatto, Mehdi W. Fawaz, Benoit Mahler, Arnaud Sollier, Bratislav Lukic, Alexander Rack, David Amans, Vincenzo Amendola   +8 more
wiley   +1 more source

Tuning Aggregation in Liquid‐Crystalline Squaraine Chromophores

Advanced Science, EarlyView.
A novel squaraine dye (SQ) forming columnar liquid crystal (LC) phase is synthesized, whose aggregate state can be tuned without disturbing the columnar structures. The liquid crystallization not only offers a rich spectrum and tuning method of optical property but also a novel path for the prescriptive functionalization of LC SQ materials.
Tianyi Tan, Yu Cao, Changlong Chen, Sanliang Ling, Gaolei Hou, Martin J. Paterson, Xin Wang, Ying Chen, Kai Jiang, Gang He, Goran Ungar, Georg H. Mehl, Feng Liu   +12 more
wiley   +1 more source

Lung sequestration: report of seven cases and review of 540 published cases

Thorax, 1979
B. Savić, F. Birtel, W. Tholen, H. Funke, R. Knoche   +4 more
semanticscholar   +1 more source

A Reversible and Dynamic Surface Functionalization for Fluidity Controlled Multivalent Recognition of Lectins and Bacteria

Advanced Science, EarlyView.
A reversible wet chemical surface functionalization results in dynamic multivalent receptors showing ligand‐specific high affinity for lectins and bacteria. Abstract The paper reports the design of multivalent bacterial receptors based on reversible self‐assembled monolayers (rSAMs) on gold and glass substrates, mimicking the ligand display on host ...
Thomas Hix‐Janssens, Adam Tillo, Hanna Isaieva, Zita Lopes da Silva, Zahra Fatahi, Michele Larocca, Gustav Sedelius, Sara Björk Sigurdardóttir, Yulia Sergeeva, Tiba Al‐Dujaili, Julia R. Davies, Kushagr Punyani, Börje Sellergren   +12 more
wiley   +1 more source