Results 121 to 130 of about 7,327 (163)

Endovascular treatment of unruptured Spetzler-Martin grade IV and V brain AVMs in a predominantly Hispanic patient cohort. [PDF]

Interv Neuroradiol
Miller S, Abualnadi Y, Wondwossen T, Hassan A.   +3 more
europepmc   +1 more source

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Abstract 5699: Overexpression of KMT2A is associated with worse prognosis and specific immune signatures in patients with TP53-mutated hepatocellular carcinomas

Cancer Research, 2022
Abstract Background: Aberrant expression of epigenetic regulators is often associated with pathogenesis. Histone H3K4 methyltransferase, known as KMT2A, has been implicated in regulation of chromosome segregation, mitosis and DNA replication in pediatric leukemia and myeloma. However, the role of KMT2A expression in solid tumors is under-
Liang Sha, Jun Yin, Sungming Kim, Woojin An, Jian Zhang, Alex Farrell, Joanne Xiu, David Spetzler, Shuanzeng Wei, Dave S. Hoon, Stephen V. Liu, Emil Lou, Misako Nagasaka, Wafik S. El-Deiry, Benedito A. Carneiro, Wolfgang Michael Korn, Heinz-Josef Lenz, Yali Dou   +17 more
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Abstract 5699: AMV564, a bivalent, bispecific T-cell engager, depletes myeloid-derived suppressor cells and activates T cells in cancer patients

Cancer Research, 2020
Abstract Background Myeloid-derived suppressor cells (MDSC) elicit a range of suppressive functions that inhibit normal T cell responses and promote non-responsiveness to immune checkpoint blockade. While CD33 does not appear to play a significant role in differentiated myeloid cells, in immature myeloid cells CD33 signaling via ligand ...
Victoria Smith, Sterling Eckard, Michael P. Rettig, Leah N. Gehrs, Jeanmarie Guenot, Sheng Wei, John F. DiPersio   +6 more
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Abstract 5699: Detection of genetic and epigenetic DNA markers in urine for the early detection of liver cancer

Cancer Research, 2017
Abstract The purpose of this study was to explore the potential of urine DNA biomarkers for the early detection of primary hepatocellular carcinoma (HCC). HCC is an aggressive disease with a 5-year survival rate of 26% in early-stage cancers, and a mere 2% in later stages. The most commonly used screening biomarker for HCC is serum alpha-
Surbhi Jain, Jamin D. Steffen, Yih-Ping Su, Jeremy Wang, Ting-Tsung Chang, Chi-Tan Hu, Wei Song, Ying-Hsiu Su   +7 more
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Abstract 5699: Obesity-induced colon tumorigenesis is associated with increased cytokine production and alterations in microRNA expression

Cancer Research, 2010
Abstract Obesity has been associated with increased colon cancer risk. Although the molecular pathways underlying the obesity-colon cancer link are unknown, one hypothesis is obesity induces a chronic inflammatory state which increases cancer risk. MicroRNAs (miRs) are small noncoding RNAs that regulate gene expression.
Susan E. Olivo-Marston, Aaron J. Schetter, Mohammed A. Khan, Stephen D. Hursting, Rami S. Maarouf, Curtis C. Harris, Jackie Lavigne   +6 more
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Abstract 5699: A new method for evaluating T cell response after stimulation on gastrointestinal cancer patients

Cancer Research, 2018
Abstract Background: In anti-tumor immunity, T cells play a central role to eliminate cancer cells. Immune responses of T cells are initiated by communication with antigen presenting cells (APCs). It became clear that an immunological synapse (IS) is formed at the T cell-APC interface and is made up of a supramolecular activation cluster
Tomoko Tanaka, Kimihiro Yamashita, Yutaka Sugita, Eiji Fukuoka, Akira Arimoto, Yoshihiro Kakeji   +5 more
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Abstract 5699: Mesenchymal stem cells (MSCs) as a selective delivery vehicle for a PSA-activated protoxin for advanced prostate cancer

Cancer Research, 2012
Abstract Circulating bone marrow-derived Mesenchymal Stem Cells (MSCs) can differentiate into cells of the mesoderm lineage and have an innate tropism for tumor tissue in response to the inflammatory microenvironment present in malignant lesions. MSCs have been detected in the perivascular space of many tumors, including prostate.
Shuangling Chen, Nathaniel Brennen, Robert A. Brodsky, Linzhao Cheng, Samuel R. Denmeade, John T. Isaacs   +5 more
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Previous Papanicolaou and Hybrid Capture 2 human papillomavirus testing results of 5699 women with histologically diagnosed cervical intraepithelial neoplasia 2/3

Journal of the American Society of Cytopathology, 2019
Cervical cancer remains an important public health problem in Chinese women owing to the lack of a national screening program. The aim of the present study was to evaluate human papillomavirus (HPV) and Papanicolaou (Pap) test results preceding the histologic diagnosis of cervical intraepithelial neoplasia 2/3 (CIN2/3) in China's largest College of ...
Tao, Wu, Xiangbai, Chen, Baowen, Zheng, Juan, Li, Fengxiang, Xie, Xiangdong, Ding, Zhengyu, Zeng, Chengquan, Zhao   +7 more
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Abstract 5699: Development and validation of a quantitative systems pharmacology model for prediction of preclinical efficacy of PARP inhibitors rucaparib and talazoparib combined with the ATR inhibitor gartisertib (M4344)

Cancer Research, 2023
Abstract Introduction: Poly (ADP-ribose) polymerase (PARP) and ataxia telangiectasia and Rad3-related (ATR) inhibitors target key DNA damage response (DDR) kinases. PARP inhibitors (PARPi) suppress the catalytic activity of PARP and trap PARP in a complex with damaged DNA, resulting in the accumulation of unrepaired single-strand breaks (
Claire C. Villette, Frances Brightman, Nathalie Dupuy, Astrid Zimmermann, Florianne Lignet, Frank T. Zenke, Nadia Terranova, Jayaprakasam Bolleddula, Samer El Bawab, Christophe Chassagnole   +9 more
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