Results 51 to 60 of about 15,556 (202)

Investigative study on the role of the Toxo 5699 gene in the Toxoplasma gondii lytic cycle using the CRISPR/Cas9 system.

open access: yesTropical biomedicine, 2021
The focus of the current study was to disrupt the Toxo 5699 gene via CRISPR/Cas9 to evaluate the effects of gene disruption on the parasite lytic cycle. In the present work, a single plasmid expressing both the guide RNA and Cas9 nuclease together with a selectable marker of human dihydrofolate reductase (DHFR) was introduced into Toxoplasma gondii ...
J R, De Silva, X T, Ching, Y L, Lau
openaire   +1 more source

Long-term survival after venous thromboembolism: a retrospective selected cohort study among young women

open access: yesHaematologica, 2010
Few data are available on long-term survival following venous thromboembolism. We performed a retrospective survival analysis covering the period January 1985 to December 2006 in 728 young women (median age 28.7 years; interquartile range 21.6–36.3 years)
Sylvia Reitter   +5 more
doaj   +1 more source

Transcriptome-wide association study identifies genes associated with bladder cancer risk

open access: yesScientific Reports
Genome-wide association studies (GWAS) have detected several susceptibility variants for urinary bladder cancer, but how gene regulation affects disease development remains unclear.
Siting Li   +3 more
doaj   +1 more source

Out‐of‐Pocket Costs and Antidepressant Adherence in Head and Neck Cancer Survivors

open access: yesPsycho-Oncology, Volume 35, Issue 5, May 2026.
ABSTRACT Background Head and neck cancer (HNC) survivors have a high burden of depression, yet real‐world antidepressant adherence and the role of patient out‐of‐pocket (OOP) costs in this population remain poorly characterized. Methods We analyzed a retrospective cohort of US adults with HNC and a new antidepressant prescription in Merative MarketScan
Gennaro Di Tosto   +4 more
wiley   +1 more source

Effect of Tempering Temperature on Microstructure and Properties of 65Mn Spring Steel for Track and Field Starter

open access: yesMetalurgija
65Mn spring steel is a candidate material for elastic components in track and field starters due to its favorable combination of strength and elasticity.
Haiyan Ma   +3 more
doaj   +1 more source

Dissecting the Cell‐Type‐Specific Response to an Emerging Tobamovirus in Tomato Reveals Cultivar‐Dependent Involvement of Brassinosteroid Signalling

open access: yesPlant Biotechnology Journal, Volume 24, Issue 5, Page 3106-3124, May 2026.
ABSTRACT Plant viruses drive widespread crop epidemics, yet the host plant responses across different cell types, particularly how these responses are influenced by cultivars with varying genetic backgrounds, including the presence of resistance (R) genes, remain poorly understood. Using tomato brown rugose fruit virus (ToBRFV) and two tomato cultivars,
Yuhong Zhang   +8 more
wiley   +1 more source

State v. Chambers Appellant\u27s Brief Dckt. 45608 [PDF]

open access: yes, 2018
https://digitalcommons.law.uidaho.edu/not_reported/5699/thumbnail ...

core   +1 more source

Clinical effectiveness of procalcitonin‐ or C‐reactive protein‐guided antibiotic discontinuation protocols for adult patients who are critically ill with sepsis: a rapid systematic review and meta‐analysis

open access: yesAnaesthesia, Volume 81, Issue 4, Page 556-569, April 2026.
Summary Introduction Antibiotics are a first‐line treatment for sepsis, with guidelines recommending a 7‐ to 10‐day course. Prolonged antibiotic use carries significant risks, prompting growing interest in using inflammatory biomarkers, such as procalcitonin or C‐reactive protein, to guide clinical decision‐making on the duration of antibiotic therapy ...
Sonya Rafiq   +6 more
wiley   +1 more source

Resolving a Nearly Two‐Centuries‐Old Mystery: On the Structural Chemistry and Physicochemical Properties of Compounds Associated With the Term Ammelide

open access: yesChemistry – A European Journal, Volume 32, Issue 9, 2 March 2026.
The crystal structure of ammelide, also known as melanuric acid, was solved almost 200 years after its discovery by Liebig. Moreover, three modifications of its 1:1 adduct with ammeline were structurally elucidated, consisting of layers with a honeycomb motif analogous to melamine cyanurate.
Thaddäus J. Koller   +8 more
wiley   +1 more source

Application of Geographically Weighted Regression Analysis to Assess Predictors of Early Sexual Initiation in Ethiopia, EDHS 2016

open access: yesHealth Science Reports, Volume 9, Issue 3, March 2026.
ABSTRACT Background and Aims Early sexual initiation was defined as the experience of first intercourse before 18 years of age. It has negative health, social, and economic consequences with an increased lifetime prevalence of sexual partners, thereby increasing the risk of exposure to sexually transmitted diseases. Thus, this study aimed to assess the
Shimels Derso Kebede   +1 more
wiley   +1 more source

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