Results 91 to 100 of about 3,831,055 (257)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Resolución CSDEyVE N° 37/2022. Derogar la Resolución CSDEyVE N° 58/2019. Aprobar el reglamento de diplomaturas de extensión universitaria.

, 2022
Fil: Consejo Superior de Docencia, Extensión y Vida Estudiantil (D). Universidad Nacional de Río Negro. Río Negro, ArgentinaResolución CSDEyVE N° 37/2022. Derogar la Resolución CSDEyVE N° 58/2019.
Consejo Superior de Docencia, Extensión y Vida Estudiantil (D)
core  

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

The design and test of Ethernet with multiple SGMII based on FPGA

Dianzi Jishu Yingyong
Due to power consumption, size, and cost constraints, embedded processors typically integrate one or two Ethernet controllers, which cannot meet the demand for simultaneous transmission of multiple Ethernet data streams in certain specific field ...
Fu Qiang, Qiao Hui, Yang Feihu, Cao Shuanzhu, Zhang Jingfei   +4 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

(Table 2) Analytical data for step-heating experiments at DSDP Hole 58-445 and 58-446A

, 1980
(Table 2) Analytical data for step-heating experiments at DSDP Hole 58-445 and 58 ...
Minoru Ozima (6981230), Y. Takigami, I. Kaneoka, Ozima, Minoru, M. Ozima, Kaneoka, Ichiro, Ichiro Kaneoka (6981236), Takigami, Yutaka, Yutaka Takigami (6981233)   +8 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Профилактика рака и борьба с ним

, 2005
Всемирная ассамблея здравоохранения, 58 ...
Всемирная ассамблея здравоохранения, 58
core  

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Interconnect testing method for multi-chiplet heterogeneous integrated systems based on boundary scan

Dianzi Jishu Yingyong
For multi-chiplet heterogeneous complex structures, traditional functional testing methods are unable to accurately locate internal interconnection faults. A boundary-scan-based interconnect testing method for multi-chiplet is proposed, which enables the
Chen Long, Huang Jian, Xie Weikun, Song Guodong   +3 more
doaj   +1 more source