Results 171 to 180 of about 127,903 (201)
Some of the next articles are maybe not open access.
Abyssomicin Monomers and Dimers from the Marine-Derived Streptomyces koyangensis SCSIO 5802
Journal of Natural Products, 2018Three new abyssomicin monomers designated neoabyssomicins D (1), E (2), and A2 (3) and the two dimeric neoabyssomicins F (4) and G (5) were discovered from the marine-derived Streptomyces koyangensis SCSIO 5802, and their structures rigorously elucidated.
Hongbo Huang +9 more
openaire +3 more sources
Cancer Research, 2022
Abstract Background: CDK4/6 inhibitors (CDK4/6i) palbociclib (palbo) and abemaciclib (abema) have significantly improved outcomes in patients with hormonal receptor positive (HR+)/human epidermal growth factor receptor negative (HER2-) breast cancer.
Chandrashekhar Honrao +9 more
openaire +1 more source
Abstract Background: CDK4/6 inhibitors (CDK4/6i) palbociclib (palbo) and abemaciclib (abema) have significantly improved outcomes in patients with hormonal receptor positive (HR+)/human epidermal growth factor receptor negative (HER2-) breast cancer.
Chandrashekhar Honrao +9 more
openaire +1 more source
Abstract 5802: Efficacy of PI3Kβ inhibitor AZD8186 in PTEN-deficient triple-negative breast cancer
Cancer Research, 2018Abstract Background: Phosphatase and tensin homologue (PTEN) loss is a frequently disrupted tumor suppressor in cancer. PTEN serves as a negative regulator of the phosphatidylinositol 3-kinase (PI3K)/AKT/mTOR pathway to promote balanced cell proliferation, survival and differentiation.
Nicci Owusu-Brackett +5 more
openaire +1 more source
Cancer Research, 2023
Abstract Treatment of glioblastoma (GBM) is challenging due to its heterogeneous nature, invasive potential and poor response to standard of care treatments. As a result, GBM inevitably recurs and only approximately 9% of patients survive 5 years post-diagnosis.
Yamhilette Licon Munoz +5 more
openaire +1 more source
Abstract Treatment of glioblastoma (GBM) is challenging due to its heterogeneous nature, invasive potential and poor response to standard of care treatments. As a result, GBM inevitably recurs and only approximately 9% of patients survive 5 years post-diagnosis.
Yamhilette Licon Munoz +5 more
openaire +1 more source
Circulation, 2008
This is an initial report on the use of the recently introduced whole-heart 320-slice computed tomography (CT) scanner for noninvasive coronary angiography compared with conventional coronary angiography (CCA). Whole-heart CT avoids overscanning and overranging as necessary for helical coronary CT acquisitions thereby significantly reducing the ...
Marc Dewey +6 more
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This is an initial report on the use of the recently introduced whole-heart 320-slice computed tomography (CT) scanner for noninvasive coronary angiography compared with conventional coronary angiography (CCA). Whole-heart CT avoids overscanning and overranging as necessary for helical coronary CT acquisitions thereby significantly reducing the ...
Marc Dewey +6 more
openaire +1 more source
Urology, 2002
To evaluate the complication rates and possible risk factors of biopsy of the prostate, with the aim of improving patient counseling and the safety of the procedure. Biopsy of the prostate has to be a relatively safe procedure and the participants have to be well informed about the possible complications.Within the biopsy protocol of the Rotterdam ...
Raaijmakers, R +4 more
openaire +3 more sources
To evaluate the complication rates and possible risk factors of biopsy of the prostate, with the aim of improving patient counseling and the safety of the procedure. Biopsy of the prostate has to be a relatively safe procedure and the participants have to be well informed about the possible complications.Within the biopsy protocol of the Rotterdam ...
Raaijmakers, R +4 more
openaire +3 more sources
Circulation, 2009
Background: Aminopeptidase A (APA) is a membrane-bound metalloprotease degreading bioactive peptidase by cleaving from N-terminal amino acids with several functions in angiogenesis. To assess whether APA regulates ischemia-induced angiogenesis, we explored the mechanism by which APA affects angiogenesis under hypoxia conditions
Ryuji Kubota +5 more
openaire +1 more source
Background: Aminopeptidase A (APA) is a membrane-bound metalloprotease degreading bioactive peptidase by cleaving from N-terminal amino acids with several functions in angiogenesis. To assess whether APA regulates ischemia-induced angiogenesis, we explored the mechanism by which APA affects angiogenesis under hypoxia conditions
Ryuji Kubota +5 more
openaire +1 more source
2022
La presente investigación surge de la necesidad de entender los conceptos y procedimientos requeridos para formular y gestionar proyectos de investigación, desarrollo e innovación (I+D+i), que satisfagan las expectativas esperadas y de los cuales se puedan obtener resultados como nuevos conocimientos o innovaciones que beneficien a las personas ...
Natalia Molina Arévalo +2 more
openaire +1 more source
La presente investigación surge de la necesidad de entender los conceptos y procedimientos requeridos para formular y gestionar proyectos de investigación, desarrollo e innovación (I+D+i), que satisfagan las expectativas esperadas y de los cuales se puedan obtener resultados como nuevos conocimientos o innovaciones que beneficien a las personas ...
Natalia Molina Arévalo +2 more
openaire +1 more source
Journal of Physics B: Atomic and Molecular Physics, 1982
The effects of temperature upon the Ar-perturbed K I 5802 AA emission line (4p 2P32/-7s 2S12/f) were measured with a Fabry-Perot interferometer. Low-pressure measurements were made between 443 and 760K in a positive-column discharge. Computer analyses of the line shapes are based upon the semiclassical theory in the impact approximation, and ...
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The effects of temperature upon the Ar-perturbed K I 5802 AA emission line (4p 2P32/-7s 2S12/f) were measured with a Fabry-Perot interferometer. Low-pressure measurements were made between 443 and 760K in a positive-column discharge. Computer analyses of the line shapes are based upon the semiclassical theory in the impact approximation, and ...
openaire +1 more source
Cancer Research
Cutaneous immune-related adverse events (cirAEs) affect nearly one-third of patients treated with immune checkpoint inhibitors (ICIs). Identifying patients at high risk for cirAE can help guide monitoring and therapeutic management. Whether tumor somatic mutations are associated with the risk of cirAE development remains unknown.
Ninghui Hao +12 more
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Cutaneous immune-related adverse events (cirAEs) affect nearly one-third of patients treated with immune checkpoint inhibitors (ICIs). Identifying patients at high risk for cirAE can help guide monitoring and therapeutic management. Whether tumor somatic mutations are associated with the risk of cirAE development remains unknown.
Ninghui Hao +12 more
openaire +1 more source