Results 191 to 200 of about 243,130 (240)

Mucin Glycoprotein Nanoparticles Enable a Selective Antisense Therapy for Oncogenic MicroRNAs

Advanced NanoBiomed Research, EarlyView.
Mucin glycoproteins are turned into nanoparticles by employing synthetic DNA strands, which have a dual function: they stabilize the nanoparticles and act as binding sites for intracellular miRNA‐21. Thus, upon internalization into tumor cells, these mucin nanoparticles can deplete miRNA‐21 from the cytosol, which induces apoptosis in vitro and in vivo.
Ceren Kimna, Thomas Mayer, Di Zhang, Matthias Marczynski, Carolin A. Rickert, Fabio Henkel, Lennart J. K. Weiss, Friedrich C. Simmel, Yuxia Luan, Oliver Lieleg   +9 more
wiley   +1 more source

MicroRNA signatures of invasiveness in PitNETs: a focus on miR-186-5p, miR-191-5p, miR-454-3p, and miR-590-5p. [PDF]

Endocrine
Rak-Makowska B, Garbicz F, Mehlich D, Sajjad E, Kuśmierczyk Z, Zieliński G, Maksymowicz M, Doboszek S, Grzywa TM, Włodarski P, Nowis D, Ambroziak U.   +11 more
europepmc   +1 more source

NUAK2 Inhibition Enhances Macromolecular Drug Delivery in a 3D Fibrotic Model of the Pancreatic Tumor Microenvironment

Advanced NanoBiomed Research, EarlyView.
Using a 3D cell culture model of the fibrotic barrier in pancreatic cancer, this work shows that inhibiting NUAK2 kinase in pancreatic stellate cells enhances macromolecular drug delivery. Mechanistically, NUAK2 inhibition disrupted actin stress fiber assembly to downregulate collagen I expression, thus enhancing macromolecular permeability.
Misaki Nakamura, Hiroyoshi Y. Tanaka, Mayu Ohira, Haruko Ohta‐Okano, Reika Nakamura, Yu Seno, Saaya Yara, Sakura Fujita, Daichi Shibata, Masaya Yamamoto, Shinichi Toyooka, Kensuke Osada, Horacio Cabral, Atsushi Masamune, Mitsunobu R. Kano   +14 more
wiley   +1 more source

Population structure and emergence of resistance to new and repurposed drugs in XDR-TB: insights from a 10-year genomic study in the Western Cape, South Africa review. [PDF]

Front Cell Infect Microbiol
Ngom JT, Loubser J, Maasdorp E, Ghebrekristos Y, Singh S, Opperman CJ, Klopper M, Warren RM, Streicher EM.   +8 more
europepmc   +1 more source

An Fe(III)-Based Fluorescent Probe for Carbon Monoxide only Senses the "CO Donor" Used, CORM-3, but Not CO. [PDF]

Anal Chem
Li H, Liu D, Wang B.
europepmc   +1 more source

Intra-arterial thrombolysis after successful endovascular reperfusion for large vessel occlusion stroke: A meta-analysis of randomized seven controlled trials. [PDF]

Interv Neuroradiol
Mortezaei A, Al-Saidi N, Li YL, Yedavalli VS, Regenhardt RW, Dmytriw AA.   +5 more
europepmc   +1 more source

Correction: Cantile et al. Functional Interaction among lncRNA HOTAIR and MicroRNAs in Cancer and Other Human Diseases. <i>Cancers</i> 2021, <i>13</i>, 570. [PDF]

Cancers (Basel)
Cantile M, Di Bonito M, Tracey De Bellis M, Botti G.   +3 more
europepmc   +1 more source

Impact of adverse childhood experiences on health-related quality of life in Australian women with endometriosis: a population-based cohort study. [PDF]

Qual Life Res
Gete DG, Doust J, Mortlock S, Abbott J, Mishra GD.   +4 more
europepmc   +1 more source

EPSG 590

openaire   +1 more source