This study identifies L‐type calcium channel blockers as novel ferroptosis inhibitors. It reveals that PKCβ, activated in calcium dependent manner, phosphorylates and activates ACSL4 and ALOX15, relocating them to lipid droplets to promote lethal lipid peroxidation and ferroptosis.
Guoyuan Hou +8 more
wiley +1 more source
circEFR3A promotes breast cancer progression by sponging miR-590-3p to upregulate androgen receptor expression. [PDF]
Mi Y +8 more
europepmc +1 more source
We have developed a glucose‐triggered on‐demand drug delivery CF‐CPGaMPN hydrogel based on borate ester bonds. It inactivates microbes, releases oxygen, and enables on‐demand drug release in high‐glucose environments to promote healing of diabetic wounds. Single‐cell sequencing reveals that the CF‐CPGaMPN hydrogel significantly alleviates dysfunctional
Manxuan Liu +8 more
wiley +1 more source
Correction: Arylazobenzimidazoles: versatile visible-light photoswitches with tuneable <i>Z</i>-isomer stability. [PDF]
Steinmüller SAM +5 more
europepmc +1 more source
The All-Persian Synod of Christians, convened by shāhanshāh Khosrow II Parviz (590–628)
Arsen K. Shahinyan
openalex +1 more source
Combination of Endothelial-Monocyte-Activating Polypeptide-II with Temozolomide Suppress Malignant Biological Behaviors of Human Glioblastoma Stem Cells via miR-590-3p/MACC1 Inhibiting PI3K/AKT/mTOR Signal Pathway [PDF]
Wei Zhou +7 more
openalex +1 more source
All‐PEG‐Like Block Copolymers Self‐Assemble into Stealth Nanocarriers for Drug Delivery
Self‐assembling nanoparticles composed entirely of POEGMA are engineered by exploiting side‐chain–dependent amphiphilicity and tunable thermoresponsive behavior. These single‐material nanocarriers encapsulate diverse hydrophobic drugs with high efficiency, retain therapeutic activity, improve in vivo efficacy, and evade anti‐PEG antibodies.
Parul Sirohi +15 more
wiley +1 more source
Powering Molecular Motors with Light Across the Rainbow Using Quantum Dots. [PDF]
Liu J +9 more
europepmc +1 more source
A multifunctional injectable microsphere system is fabricated via UV‐assisted microfluidic cross‐linking, integrating nanozyme‐based ROS scavenging, sustained dexamethasone release, and stem cell delivery. Upon IA injection, the microspheres adapt to joint stress, suppress inflammation, and promote cartilage regeneration, offering a minimally invasive ...
Xiaochen Feng +10 more
wiley +1 more source
Multidrug Resistance in Bacterial Isolates from Clinical Samples Submitted to a National Veterinary Diagnostic Facility in Uganda (2014-2020): A Retrospective Analysis. [PDF]
Kakooza S +12 more
europepmc +1 more source

