Results 271 to 280 of about 1,318,093 (377)

Cost-effectiveness analysis of pembrolizumab plus chemotherapy versus chemotherapy as first line chemotherapy for patients with unresectable advanced esophageal cancer in Japan. [PDF]

Esophagus
Kakinuma H, Takada D, Itoshima H, Kunisawa S, Moriwaki K, Honda M, Fushimi K, Imanaka Y.   +7 more
europepmc   +1 more source

Nicotine Reprograms Aging‐Related Metabolism and Protects Against Motor Decline in Mice

Advanced Science, EarlyView.
Long‐term oral nicotine intake protects against age‐related motor decline in mice without eliciting systemic toxicity. Integrated multi‐organ metabolomic profiling and longitudinal gut microbiota analyses reveal that nicotine induces coordinated remodeling of glycolipid and sphingolipid metabolism, enhances NAD⁺ bioavailability, and suppresses ceramide
Shuhui Jia, Xiaoyuan Jing, Ruoxi Wang, Mengke Su, Pei Wang, Yingxin Feng, Xiaohu Ren, Longfang Tu, Ping Wei, Zhen Lu, Yicong Jia, Feng Hong, Zhizhun Mo, Jiemeng Zou, Kang Huang, Caiyun Yan, Qianhui Zou, Liang Wang, Guoping Zhong, Zhi Zeng, Qiuliyang Yu, Wen Su, Xifei Yang, Fan Pan, Jianzhi Wang, Liping Wang, Lijun Kang, Paul J. Kenny, Zuxin Chen, Xin‐an Liu   +29 more
wiley   +1 more source

Intense Pulsed Light Improves Facial Telangiectasia and Acne-Induced Post-Inflammatory Erythema in Systemic Lupus Erythematosus Patient: A Case Report. [PDF]

J Cosmet Dermatol
Li Z, Lu J, Wu M.
europepmc   +1 more source

Regular versus Irregular Exercise Differentially Modulates Hippocampal‐Hepatic Acetylcholine Flux to Coordinate Fear Memory Extinction and Liver Inflammation

Advanced Science, EarlyView.
Ma et al. report the hippocampal and hepatic acetylcholine (ACh) levels are differently modulated by regular versus irregular exercise, which contributes to coordinate hippocampal astrocyte activity and hepatic FBXL6high neutrophil recruitment. This ACh‐modulated brain‐liver circuit links the effects of exercise on fear memory extinction and liver ...
Pengjiao Ma, Kuan Zhang, Long Yi, Chuanyan Yang, Hedong Lang, Jianbin Sun, Jin Li, Qian Bai, Yuhang He, Shuang‐Shuang Dai, Man‐Tian Mi   +10 more
wiley   +1 more source

Development and validation of a prognostic prediction model for patients with lung metastasis of esophageal cancer. [PDF]

World J Surg Oncol
Si X, Gao L, Zhu Y, Chen J, Chen Z, Chen X.   +5 more
europepmc   +1 more source

Ultrathin Multi‐Doped Molybdenum Oxide Nanodots as a Tunable Selective Biocatalyst

Advanced Science, EarlyView.
This paper presents an advanced multi‐doped molybdenum oxide nanodots with tunable ammonium and proton doping, exhibiting strong ROS generation. The material demonstrates ultrafast and complete dye degradation and unique selective toxicity toward cancer cells, highlighting its promising potential for cancer therapy applications.
Bao Yue Zhang, Farjana Haque, Shwathy Ramesan, Sanjida Afrin, Muhammad Waqas Khan, Haibo Ding, Xin Zhou, Qijie Ma, Jiaru Zhang, Rui Ou, Md Mohiuddin, Enamul Haque, Yichao Wang, Azmira Jannat, Yumin Li, Robi S. Datta, Kate Fox, Guolang Li, Hujun Jia, Jian Zhen Ou   +19 more
wiley   +1 more source

A dual-functional substrate for quantitation of substrate levels and GCase activity in living cells. [PDF]

RSC Chem Biol
Tiet B, Zhu S, Chen X, Anastasi N, See NW, Deen MC, Harde E, Vocadlo DJ.   +7 more
europepmc   +1 more source

Melatonin Modulates Glucose Metabolism Reprogramming via Targeting G6PD to Alleviate Lead‐Induced Hepatocytes Pyroptosis in Common Carp (Cyprinus carpio L.)

Advanced Science, EarlyView.
This study reveals that Lead reprograms glucose metabolism to enhance H3K18la, driving DRP1‐dependent mitochondrial DNA leakage and cGAS‐STING‐mediated pyroptosis. Melatonin targets G6PD to suppress glycolysis‐driven H3K18la and restore mitochondrial homeostasis, thereby alleviating Lead‐induced liver injury in common carp through disruption of the ...
Zhiying Miao, Xiaofeng Ji, Lai Wei, Zhiruo Miao, Shiwen Xu   +4 more
wiley   +1 more source

Multipronged SMAD pathway targeting by lipophilic poly(β-amino ester) miR-590-3p nanomiRs inhibits mesenchymal glioblastoma growth and prolongs survival. [PDF]

Signal Transduct Target Ther
Korleski J, Sall S, Luly KM, Johnson MK, Johnson AL, Khela H, Lal B, Taylor TC, Ashby JM, Alonso H, Li A, Zhou W, Smith-Connor K, Hughes R, Tzeng SY, Laterra J, Green JJ, Lopez-Bertoni H.   +17 more
europepmc   +1 more source

Subventricular Zone‐on‐a‐Chip: A Model to Study Neurogenesis Disruption in Neonatal Intraventricular Hemorrhage

Advanced Science, EarlyView.
A human subventricular zone‐on‐a‐chip is developed to model intraventricular hemorrhage (IVH) in preterm infants. This platform enables the study of inflammation‐driven neurogenic disruption. Exposure to hemorrhagic cerebrospinal fluid and red blood cell lysate activated inflammatory pathways, with IL1B emerging as a key mediator.
Laura Nicoleti Zamproni, Begüm Gökçe, Magnus Gram, Coco Holliday, Aylin Sendemir, Marimélia Aparecida Porcionatto, Anna Herland   +6 more
wiley   +1 more source