Results 311 to 320 of about 1,350,327 (326)

M2 macrophage-derived exosomal-miR-590-3p attenuates DSS-induced mucosal damage and promotes epithelial repair via the LATS1/YAP/β-catenin signalling axis.

Journal of Crohn's & Colitis, 2020
BACKGROUND AND AIMS M2 phenotype macrophages are involved in the resolution of inflammation and intestinal repair. Exosomes are emerging as important mediators of intercellular communication in the mucosal microenvironment.
Feihong Deng, Jin Yan, Jiaxi Lu, Min Luo, Pianpian Xia, Siliang Liu, Xue-hong Wang, Fachao Zhi, Deliang Liu   +8 more
semanticscholar   +1 more source

Exosomes-Mediated LncRNA ZEB1-AS1 Facilitates Cell Injuries by miR-590-5p/ETS1 Axis Through the TGF-β/Smad Pathway in Oxidized Low-density Lipoprotein-induced Human Umbilical Vein Endothelial Cells.

Journal of Cardiovascular Pharmacology, 2021
Atherosclerosis is a chronic lipid-induced inflammation of the vessel wall. Oxidized low-density lipoprotein was confirmed to drive the onset of atherogenesis.
Difang Chen, Kunwei Wang, Yan Zheng, Guangyu Wang, Mei Jiang   +4 more
semanticscholar   +1 more source

LncRNA MALAT1 Promotes STAT3-Mediated Endothelial Inflammation by Counteracting the Function of miR-590

Cytogenetic and Genome Research, 2020
The excessive production of inflammatory mediators by vascular endothelial cells (ECs) greatly contributes to the development of atherosclerosis. In this study, we explored the potential effect of lncRNA MALAT1 on endothelial inflammation.
Qing Zhou, Qi Run, Chenyu Li, Xiang-Yu Xiong, Xiaolin Wu   +4 more
semanticscholar   +1 more source

LncRNA-ATB Promotes Lung Squamous Carcinoma Cell Proliferation, Migration, and Invasion by Targeting MicroRNA-590-5p/NF90 Axis.

DNA and Cell Biology, 2020
Lung cancer with highest morbidity and mortality seriously threatens human health worldwide. Long noncoding RNAs (lncRNAs) exert important biological functions by acting as microRNA, which is implicated in tumorigenesis and cancer development.
Jiayi Li, Rongmu Xia, Tao Liu, Xuemin Cai, Guo-jun Geng   +4 more
semanticscholar   +1 more source

Alteration of miR-21, miR-433 and miR-590 tissue expression related to the TGF-β signaling pathway in ulcerative colitis patients

Archives of Physiology and Biochemistry, 2020
Ulcerative colitis (UC) is an inflammatory disease, and studies have suggested a role for TGF-β signalling pathway in the pathogenesis of UC. In the present study, we evaluated expression of TGF-β signalling genes and their regulatory microRNAs in ...
Mehri Naghdalipour, N. Moradi, R. Fadaei, Shekufe Rezghi Barez, S. Sayyahfar, M. Mokhtare, Toktam Kazemi Fard, S. Fallah, Aboulreza Esteghamati   +8 more
semanticscholar   +1 more source

Pembrolizumab plus chemotherapy versus chemotherapy alone for first-line treatment of advanced oesophageal cancer (KEYNOTE-590): a randomised, placebo-controlled, phase 3 study

The Lancet, 2021
Jong-Mu Sun, L. Shen, M. Shah, P. Enzinger, A. Adenis, T. Doi, T. Kojima, J. Metges, Zhigang Li, Sung-Bae Kim, B. Cho, Wasat Mansoor, Shau-Hsuan Li, P. Sunpaweravong, M. Maqueda, E. Goekkurt, H. Hara, L. Antunes, C. Fountzilas, A. Tsuji, V. C. Oliden, Qi Liu, Sukrut Shah, P. Bhagia, Ken Kato   +24 more
semanticscholar   +1 more source

LncRNA FTX Promotes Colorectal Cancer Cells Migration and Invasion by miRNA-590-5p/RBPJ Axis

Biochemical Genetics, 2021
Guofang Chen, Zhiqiang Liao, Jiao Liu, Fang Li, Da-xiong Huang, Ya-Dong Zhou   +5 more
semanticscholar   +1 more source