Results 101 to 110 of about 710,562 (363)

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Internet of Things (IoT) for Next-Generation Smart Systems: A Review of Current Challenges, Future Trends and Prospects for Emerging 5G-IoT Scenarios

IEEE Access, 2020
The Internet of Things (IoT)-centric concepts like augmented reality, high-resolution video streaming, self-driven cars, smart environment, e-health care, etc. have a ubiquitous presence now. These applications require higher data-rates, large bandwidth,
Kinza Shafique, B. A. Khawaja, Farah Sabir, S. Qazi, Muhammad Mustaqim   +4 more
semanticscholar   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

A Measurement-Based Power Consumption Model for Networks With Intelligent Control (RIC)

IEEE Open Journal of the Communications Society
Open Radio Access Network (Open RAN) triggers a shift towards multi-vendor deployments with increased programmability, flexibility, and intelligence. Still, several critical questions remain unanswered, particularly regarding Open RAN's impact on power ...
Joao Paulo S. H. Lima, George N. Katsaros, Rahim Tafazolli, Konstantinos Nikitopoulos   +3 more
doaj   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

A Survey of Self-Interference Management Techniques for Single Frequency Full Duplex Systems

IEEE Access, 2018
This paper presents a comprehensive survey of the literature on self-interference management schemes required to achieve a single frequency full duplex (FD) communication in wireless communication networks.
Chinaemerem David Nwankwo, Lei Zhang, Atta Quddus, Muhammad Ali Imran, Rahim Tafazolli   +4 more
doaj   +1 more source

UAV Communications for 5G and Beyond: Recent Advances and Future Trends [PDF]

IEEE Internet of Things Journal, 2019
Providing ubiquitous connectivity to diverse device types is the key challenge for 5G and beyond 5G (B5G). Unmanned aerial vehicles (UAVs) are expected to be an important component of the upcoming wireless networks that can potentially facilitate ...
Bin Li, Zesong Fei, Yan Zhang
semanticscholar   +1 more source

Ro 31‐8220 suppresses bladder cancer progression via enhancing autophagy in vitro and in vivo

FEBS Open Bio, EarlyView.
The pan‐protein kinase C inhibitor Ro‐31‐8220 demonstrates potent anti‐bladder cancer effects both in vitro and in vivo by suppressing migration/invasion, inducing apoptosis and crucially activating autophagy, where blocking autophagy with chloroquine reduces its cell‐killing efficacy, suggesting its promise as a novel therapeutic candidate requiring ...
Shengjun Fu, Yan Tao, Shan Wu, Yuwen Gong, Youli Zhao, Shaomin Niu, Hui Cheng, You Mu, Na Xu, Ying Wang, Jianzhong Lu, Shanhui Liu, Lanlan Li   +12 more
wiley   +1 more source

Age‐Related Changes in Myeloid Cells and Their Impact on Subcutaneous Melanoma Growth in Mice

Aging and Cancer, EarlyView.
Our findings reveal that age‐related changes in subcutaneous melanoma growth and immunotherapy response are context‐dependent. In models where tumor growth and treatment resistance increase with age, this effect is partly driven by enhanced immunosuppression from myeloperoxidase‐active Gr‐1⁺ myeloid cells.
Kaitlyn M. Landreth, Dylan D. Thomas, Remi Nohoesu, Angisha Basnet, F. Heath Damron, Mary Garland‐Kledzik, Emel Sen Kilic, Tracy W. Liu   +7 more
wiley   +1 more source

Enhancing 5G propagation into vehicles and buildings using optically transparent and polarisation insensitive metasurfaces over wide-incidence angles

Scientific Reports
This article introduces two transmissive metasurfaces applied to normal windows, aiming to improve the 5G outdoor-to-indoor (O2I) coverage. These windows can be utilized in various settings, such as vehicles or buildings.
Amirmasood Bagheri, Shadi Danesh, Fan Wang, Seyed Ehsan Hosseininejad, Mohsen Khalily, Rahim Tafazolli   +5 more
doaj   +1 more source