Results 131 to 140 of about 38,687 (246)

Pathological Mechanism‐Inspired Biomimetic Nano‐Senotherapy for Reversing Experimental Atherosclerosis in ApoE−/− Mice

Advanced Science, EarlyView.
The biomimetic self‐assembly nanomedicine reversing atherosclerosis via senotherapy strategy. ABSTRACT The greatest challenge in atherosclerosis (AS) management lies in achieving lesion reversal, not merely slowing progression. Senescent cell accumulation—driven by continuous generation and apoptotic resistance—perpetuates plaque pathology and ...
Yuhan Tian, Yanrui Yang, Qiuyu Li, Ying Hu, Qin Hu, Shasha Ran, Siyu Zhou, Xiujuan Yang, Shanshan Li, Qixiong Zhang   +9 more
wiley   +1 more source

Mobile Network Softwarization: Technological Foundations and Impact on Improving Network Energy Efficiency. [PDF]

Sensors (Basel)
Lorincz J, Kukuruzović A, Begušić D.
europepmc   +1 more source

Protein Structuromics Reveals a Loop‐Controlled Half‐Open Active Pocket Conformation Throughout Fe(II)/α‐ketoglutarate‐Dependent Dioxygenase Catalytic Cycle

Advanced Science, EarlyView.
This study reveals a conserved half‐open active pocket in Fe(II)/α‐ketoglutarate‐dependent dioxygenases through protein structuromics, distinguished by structural features comprising highly flexible loop elements. Enhanced sampling simulations‐guided mutagenesis experiments elucidated how this flexible loop regulates pocket open/closed conformations ...
Lunjie Wu, Huan Liu, Songyin Zhao, Lei Qin, Jiarui Li, Jun Wang, Zixuan Dai, Jie Gu, Yan Xu, Feiran Li, Yao Nie   +10 more
wiley   +1 more source

5G Bedside Interactive Terminal Health Education to Enhance Treatment Adherence in Elderly Patients with Chronic Diseases: The Mediating Role of Self-Efficacy. [PDF]

Patient Prefer Adherence
Zhang S, Ruan X.
europepmc   +1 more source

Single‐Cell Annotation and Localization via Integrating Spatial Transcriptomics Maps the Mouse Ocular Atlas and RAO Dynamics

Advanced Science, EarlyView.
We developed the ASCAL pipeline, integrating complementary spatial transcriptomics, to construct a high‐fidelity mouse whole‐eye single‐cell atlas. Applying ASCAL to a retinal artery occlusion (RAO) model revealed spatially restricted immune activation localized to the ganglion cell layer and the selective depletion of a translationally active, outer ...
Chen Du, Yinming Li, Ziyue Li, Yuedan Wang, Shaopeng Li, Yijie Wang, Yingying Qu, Bingyang Lv, Ying Li, Ting Chen, Yu Zhou, Xuan Xiao   +11 more
wiley   +1 more source

Low-altitude economy: next frontier in spatial exploration and economic development. [PDF]

Natl Sci Rev
Shum HY, Li S.
europepmc   +1 more source

In Situ Pseudo‐Halide Diffusion Enables Buried Interface Regulation and Crystallinity Enhancement in Perovskite Solar Cells

Advanced Science, EarlyView.
Thermally activated LiHCOO induces in situ pseudo‐halide diffusion, promoting buried interface strain release and perovskite crystallization. The monoclinic LiHCOO phase forms an open framework structure that enhances HCOO− diffusion and drives interfacial restructuring.
Chao Gao, Li He, Changjiang Li, Long Fang, Wenzhong Shen   +4 more
wiley   +1 more source

Cell Complexity Impact on Railway 5G Performance: Measurements Along Tallinn-Tartu Corridor. [PDF]

Sensors (Basel)
Pilvik R, Jairus T, Sadam A, Kõrbe Kaare K.   +3 more
europepmc   +1 more source

NIR‐II‐Trackable LYTACs Phyto‐Nanotheranostics for Source‐Microenvironment Dual‐Track ROS Regulation in Acute Gouty Arthritis

Advanced Science, EarlyView.
The TPR‐LYTACs nanomaterial offers a dual‐pathway strategy for precise gouty arthritis treatment by targeting and degrading the ROS‐producing enzyme NOX2 inside macrophages while its antioxidant core clears accumulated ROS outside. This “source inhibition and microenvironment scavenging” approach, guided by NIR‐II imaging, effectively controls local ...
Jian Zhang, Yingying Wang, Lujie Yu, Chunmei Jiang, Haoyu Liu, Yaohua Chen, Shutong Wu, Qin Liu, Lingling Wei, Xiaochun Zheng, Huifang Hao, Mengting Gao, Weiwei Kang, Rong Dai, Ziliang Zheng, Ruiping Zhang   +15 more
wiley   +1 more source

Multi-agent reinforcement learning driven resource game optimization for network slicing in MEC-enabled HetNets. [PDF]

Sci Rep
Mao K.
europepmc   +1 more source