Rab1A Promotes Hepatic Steatosis by Suppressing Mitophagy via the Raf‐1/ERK1/2/PINK1 Signaling Axis
Why does fat accumulate in the liver? Our study reveals Rab1A as the molecular switch that silences the cell's mitochondrial cleanup crew. Turning Rab1A off reactivates mitophagy, clears excess fat, and reverses fatty liver disease in mice—offering a promising new therapeutic target for MASLD, a growing global health challenge.
Li Zhang +9 more
wiley +1 more source
Binary PSO with Classification Trees Algorithm for Enhancing Power Efficiency in 5G Networks. [PDF]
Osama M, El Ramly S, Abdelhamid B.
europepmc +1 more source
This study reveals a copper‐driven mechanism of COPD acute exacerbations mediated by the TNF‐α/ATP7A axis. TNF‐α suppresses the copper transporter ATP7A via competitive NF‐κB/CREB1/CBP signaling, resulting in intracellular copper accumulation, mitochondrial oxidative stress, and epithelial barrier disruption.
Xinru Xiao +7 more
wiley +1 more source
Machine learning-enhanced 3GPP channel modeling for 5G networks: A vendor-calibrated framework with cross-scenario validation. [PDF]
Sagor MIK, Rahman MZ, Mandal P.
europepmc +1 more source
Investigating UAV-Based Applications in Indoor-Outdoor Sports Stadiums and Open-Air Gatherings for Different Interference Conditions beyond 5G Networks. [PDF]
Gupta A +9 more
europepmc +1 more source
Schematic showing a stretchable triboelectric nanogenerator based on interlocked wavy architectures that uses EGaIn microflower‐embedded PVDF‐TrFE and Nylon‐6 nanofiber membranes. The multi‐petaled, electron‐rich EGaIn microflowers enhance interfacial polarization and capacitance, while the interlocked wavy architecture enlarges the effective contact ...
Qianqian Xu +12 more
wiley +1 more source
A reconfigurable MTM-EMBG MIMO antenna array with solar panel integration for sustainable 5G networks. [PDF]
Al-Attar S +12 more
europepmc +1 more source
Game-o-Meta: Trusted Federated Learning Scheme for P2P Gaming Metaverse beyond 5G Networks. [PDF]
Bhattacharya P +8 more
europepmc +1 more source
Gemcitabine resistance remains a major challenge in pancreatic ductal adenocarcinoma. This study identifies STYK1 as a key mediator of chemoresistance through autophagy‐dependent maintenance of cancer stemness. Gemcitabine‐activated AMPK phosphorylates STYK1 at Ser91 and Ser304, enhancing autophagy and stemness.
Xueying Dong +20 more
wiley +1 more source
Reinforcement learning based resource allocation scheme for vehicular communication in 5G networks for smart cities. [PDF]
Brindha S +3 more
europepmc +1 more source

