Results 201 to 210 of about 14,599 (301)

Revisiting Target‐Aware de novo Molecular Generation with TarPass: Between Rational Design and Texas Sharpshooter

open access: yesAdvanced Science, EarlyView.
TarPass provides a rigorous benchmark for target‐aware de novo molecular generation by jointly evaluating protein‐ligand interactions, molecular plausibility, and drug‐likeness on 18 well‐studied targets. Results show that current models often fail to consistently surpass random baseline in target‐specific enrichment, while post hoc multi‐tier virtual ...
Rui Qin   +11 more
wiley   +1 more source

Wireless, Adaptable and Fully Implantable Battery‐powered Devices for Optical Stimulation of the Spinal Cord in Small Rodents

open access: yesAdvanced Science, EarlyView.
Current technologies for spinal cord optogenetic stimulation rely on external power sources and face reliability constraints in freely behaving animals. Here, a fully implantable, battery‐powered optoelectronic device is introduced, enabling operation in any selected environment with wireless recharging for months‐long stimulation.
Shahriar Shalileh   +8 more
wiley   +1 more source

T Cell‐Independent Role of PD‐L1 in Kidney Repair: Mitigation of Tubular DNA Damage via PD‐L1/BRCA1 Interaction Following AKI

open access: yesAdvanced Science, EarlyView.
PD‐L1 is primarily expressed in renal tubules and upregulated in both murine models of AKI and renal biopsy samples from patients with AKI. PD‐L1 can promote adaptive TECs repair through interacting with BRCA1, independent of its canonical immunomodulatory function of T cells, and PD‐L1 supplementation may represent a promising therapeutic strategy for
Wei Jiang   +17 more
wiley   +1 more source

Electrostatic Self‐Assembly Induced Nest‐Like MXene Networks on Fabric for Ultra‐Broadband Flexible Absorption

open access: yesAdvanced Science, EarlyView.
In this study, an electrostatically self‐assembled WPU‐MXene@FC flexible fabric constructs a “nest‐like” structure on fibers, building construct MXene multiple loss paths, achieving ultra‐wideband absorption of 25.3–1200 GHz in a thickness of 1.8 mm, while also exhibiting superhydrophobicity, acid and alkali resistance, and bending resistance ...
Min Luo   +7 more
wiley   +1 more source

Tailoring Successive Magnetic‐Dielectric Synergy for Enhancing Electromagnetic Absorption in Ultralong Heterostructure Chains Assisted by High Static Magnetic Field

open access: yesAdvanced Science, EarlyView.
This work proposes a high static magnetic field (HSMF) driven dual‐low‐dimension strategy for fabricating magnetic‐dielectric heterostructure (Fe3O4@MoS2) chains with programmable lengths. The constructed successive magnetic‐dielectric synergy, arising from uniaxial anisotropy‐enhanced magnetic response and abundant heterointerfaces that boost ...
Zhuolin Li   +5 more
wiley   +1 more source

Impedance‐Matched High‐Overtone Thickness‐Shear Bulk Acoustic Resonators With Scalable Mode Volume

open access: yesAdvanced Science, EarlyView.
A bottom‐electrode‐free high‐overtone bulk acoustic resonator is achieved by lateral excitation of antisymmetric thickness‐shear modes on a lithium‐niobate‐on‐silicon platform. Planar electrode geometry eliminates conventional loading along the resonance path and confines acoustic energy within the electrode gap.
Zi‐Dong Zhang   +7 more
wiley   +1 more source

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