Results 161 to 170 of about 11,938 (197)

SORL1 variant links endosomal amyloid precursor protein mis‐sorting to axonal transport defects and neuronal dysfunction

Alzheimer's &Dementia, Volume 22, Issue 8, August 2026.
Abstract INTRODUCTION SORL1 encodes the sorting receptor SORLA, a major genetic contributor to Alzheimer's disease (AD). Although SORL1 loss disrupts endosomal trafficking and promotes amyloidogenic amyloid precursor protein (APP) processing, the functional consequences of specific missense variants in human neurons remain unclear.
Miriam Lep, Klara Plesingrova, Jiri Sedmik, Sona Cesnarikova, Monica Feole, Ondrej Bernatik, Victorio Martin Pozo Devoto, Hana Hribkova, Katerina Amruz Cerna, Petr Fojtik, Nadezda Vaskovicova, Simona Bartova, Veronika Pospisilova, Tereza Vanova, Olav Michael Andersen, Dasa Bohaciakova, Jan Raska   +16 more
wiley   +1 more source

Optimizing 5G NR link layer parameters for eMBB and URLLC applications under dynamic channel and transmission configurations. [PDF]

Sci Rep
Pateriya S, Bandopadhaya S, Bairwa AK, Jain V.   +3 more
europepmc   +1 more source

Targeting the NAT1‐ENO1‐Lactate Axis Destabilizes PD‐L1 to Reinvigorate Antitumor Immunity in Colorectal Cancer

MedComm, Volume 7, Issue 8, August 2026.
NAT1 downregulates PD‐L1 protein expression by acetylating ENO1, which inhibits lactate‐fueled TRAF6/PD‐L1 signaling (left). Conversely, NAT1 deficiency in CRC cells enhances ENO1 activation, leading to increased glycolysis and lactate production. The lactate then binds to TRAF6, promoting its oligomerization and activation.
Yi‐Xuan Liu, Wen‐Xin Wu, Yang Zang, Guang Hu, Xin Guo, Yi Wang, Yun Yang, Zhi Jiang, Xiu‐Ming Li, Feng Liu, Yue‐Yue Wu, Zu‐Da Pan, Yuan‐Meng Hu, Ruo‐Yang Zhang, Hai‐Yi Zhang, Ping‐An Chang, Xiao‐Shun He, Wen‐Juan Gan, Hua Wu   +18 more
wiley   +1 more source

An ultra-compact and high isolated 8 × 8 MIMO antenna system for 5G NR-n46 and n79 band applications. [PDF]

Sci Rep
Mishra B, Sethumadhavi R, Singh S, Sayeed SS, Singh AK, Pandey A, Ali T.   +6 more
europepmc   +1 more source

Resmetirom Ameliorates Fibrogenesis in Hepatic Stellate Cells via Thyroid Hormone Receptor Alpha‐Fatty‐Acid Amide Hydrolase 1 Signaling Pathway

MedComm, Volume 7, Issue 8, August 2026.
1. Resmetirom attenuates the activation of HSCs induced in in vitro and in vivo models. 2. Resmetirom attenuates the activation of HSCs through its specific action on the thyroid hormone receptor alpha. 3. Resmetirom requires fatty‐acid amide hydrolase 1 to reduce HSC activation. ABSTRACT Resmetirom is a liver‐directed, thyroid hormone receptor β (THRβ)
Eva Novoa, Alba Cabaleiro, Borja López‐Picallo, Natalia da Silva Lima, Cristina Riobello, Carmen Pena, Jose Iglesias‐Moure, Ana Senra, Maria Luz Martínez‐Chantar, Anabel Fernandez‐Iglesias, Jordi Gracia‐Sancho, Susana Bravo, Carlos Dieguez, Marta Varela‐Rey, Vincent Prevot, Markus Schwaninger, Miguel López, Rubén Nogueiras   +17 more
wiley   +1 more source

Exposure to 5G-NR electromagnetic fields affects larval development of Aedes aegypti mosquito. [PDF]

Sci Rep
De Borre E, De Massia C, Boone MN, Müller P, Thielens A.   +4 more
europepmc   +1 more source

Harnessing edge computing and citizen science: A new prototype design for continental‐scale acoustic monitoring in Australia and beyond

Methods in Ecology and Evolution, Volume 17, Issue 8, Page 2295-2308, August 2026.
Abstract Inadequate monitoring of biodiversity is a characteristic of conservation the world over. The potential of acoustic monitoring is compelling, although the challenges remain substantial. Effective solutions require transdisciplinary collaboration among stakeholders, a focus on open‐source development, and flexible, multipronged technical ...
Andrea S. Griffin, Oliver Kelly, Eric Johns, Stephan Chalup, Alex Callen, Darren Southwell, Matt W. Hayward, Ysobel Sims   +7 more
wiley   +1 more source

Dual-band patch antenna for 5G NR (n48, n46, n77, n78), Wi-Fi, and indoor wireless applications. [PDF]

Sci Rep
Singh PP, Sorathiya V, Al-Zahrani FA.
europepmc   +1 more source

Lactiplantibacillus plantarum AS21 Attenuates Sex‐Biased Glucose Intolerance in Aging Mice via Gut Mucosal Microbiota‐Derived Citrulline

Aging Cell, Volume 25, Issue 8, August 2026.
Aging induces sex‐differential glucose intolerance, with male‐specific citrulline depletion. Lactiplantibacillus plantarum AS21 elevates microbiota‐derived citrulline metabolism and enhances GLP‐1 secretion, improving glucose homeostasis. ABSTRACT Aging‐related metabolic decline, particularly impaired glucose tolerance, represents a growing challenge ...
Mengya Jia, Mengyan Chen, Hu Chen, Huiling Zhang, Ruixue Dou, Chaorui Wang, Muhammad Ishaq, Xiaoying Wei, Zitong Ding, Xusheng Guo   +9 more
wiley   +1 more source

A Dendrite‐Resistant Sodium/Porous‐Carbon Anode for Solid‐State Batteries: Strategies and Challenges for Low‐Pressure Operation

ChemSusChem, Volume 19, Issue 14, 29 July 2026.
Sodiophilic mesoporous carbon confers a near‐perfect interface between Na metal and ceramic solid electrolytes, while serving as a host for solid Na anodes. This synergy forms a foundational element for sodium solid‐state batteries (Na‐SSBs) in pairing a dendrite‐resistant anode with an inherently (electro)chemically stable ceramic electrolyte.
J. Mark Weller, Joseph P. Quinn, Evgueni Polikarpov, Henry Hyungkyu Han, Marcos Lucero, Guosheng Li   +5 more
wiley   +1 more source