A Nuphar lutea Plant Active Ingredient, 6,6′-Dihydroxythiobinupharidine, Ameliorates Kidney Damage and Inflammation in a Mouse Model of Chronic Kidney Disease [PDF]
Scientific ReportsChronic Kidney Disease (CKD) associated complications are associated with increased inflammation through the innate immune response, which can be modulated with anti-inflammatory agents. An active ingredient derived from the Nuphar lutea aquatic plant, 6,
Daniel Landau +2 more
exaly +3 more sources
6,6′-Dihydroxythiobinupharidine (DTBN) Purified from Nuphar lutea Leaves Is an Inhibitor of Protein Kinase C Catalytic Activity [PDF]
Molecules, 2021 Water lily (Nuphar) bioactive extracts have been widely used in traditional medicine owing to their multiple applications against human ailments. Phyto-active Nuphar extracts and their purified and synthetic derivatives have attracted the attention of ...
Kamran Waidha +6 more
doaj +2 more sources
Inhibition of Cysteine Proteases by 6,6′-Dihydroxythiobinupharidine (DTBN) from Nuphar lutea [PDF]
Molecules, 2021 The specificity of inhibition by 6,6′-dihydroxythiobinupharidine (DTBN) on cysteine proteases was demonstrated in this work. There were differences in the extent of inhibition, reflecting active site structural-steric and biochemical differences ...
Kamran Waidha +5 more
doaj +2 more sources
Cytotoxicity of Thioalkaloid-Enriched Nuphar lutea Extract and Purified 6,6′-Dihydroxythiobinupharidine in Acute Myeloid Leukemia Cells: The Role of Oxidative Stress and Intracellular Calcium [PDF]
Pharmaceuticals, 2022 Acute myeloid leukemia (AML) is an aggressive hematological malignancy characterized by uncontrolled proliferation of immature myeloid progenitors. Here, we report the in vitro antileukemic effects of the sesquiterpene thioalkaloid-enriched fraction of ...
Suchismita Muduli +3 more
doaj +2 more sources
Anti-Leishmania major Properties of Nuphar lutea (Yellow Water Lily) Leaf Extracts and Purified 6,6′ Dihydroxythiobinupharidine (DTBN) [PDF]
PathogensCutaneous leishmaniasis (CL) is a zoonotic disease, manifested as chronic ulcers, potentially leaving unattractive scars. There is no preventive vaccination or optimal medication against leishmaniasis. Chemotherapy generally depends upon a small group of
Orit Shmuel +6 more
doaj +2 more sources
6,6’-Dihydroxythiobinupharidine as a Poison of Human Type II Topoisomerases [PDF]
Bioorganic and Medicinal Chemistry Letters, 2019 Jacob Gopas +2 more
exaly +2 more sources
In Vitro and In Vivo Therapeutic Potential of 6,6'-Dihydroxythiobinupharidine (DTBN) from Nuphar lutea on Cells and K18-hACE2 Mice Infected with SARS-CoV-2. [PDF]
Int J Mol Sci, 2023 Weiss S +9 more
europepmc +1 more source
Inhibition of Cysteine Proteases by 6,6′-Dihydroxythiobinupharidine (DTBN) From Nuphar lutea
Molecules, 2021Jacob Gopas +2 more
exaly