Results 31 to 40 of about 14,598,605 (264)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

The Correlation between Clean and Healthy Living Behavior and Diarrhea Incidence in Children Under Five Years Old: A Literature Review Study

Jurnal Ilmiah Kesehatan, 2022
Diarrhea is a disease often accompanied by mortality and morbidity. Its incidence increased 1% per year from 300 thousand household samples. Lack of Clean and Healthy Living Behavior (in Indonesia, namely of a program is Perilaku Hidup Bersih Sehat or ...
Dwiana Mei Desti Setyarini, Nur Hidaayah   +1 more
doaj   +1 more source

Clean Ocean Advocate, March 2008

, 2008
The monthly Clean Ocean Advocate newsletter informs citizens about critical ocean pollution issues, important meeting dates, proposed legislation, special events, and other notes of interest.

core   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Achieving SDG 6 targets: evaluating driving forces for philanthropic contributions to water accessibility in southwestern Nigeria

Applied Water Science
Access to potable water is crucial for sustaining human life and so has been listed in the Sustainable Development Goal 6. The role of philanthropists in promoting water accessibility is evident in developing regions’ urban centres.
Timothy O. Ogunbode, Victor O. Oyebamiji, Christiana O. Afolabi   +2 more
doaj   +1 more source

Clean Ocean Advocate, January 2008

, 2008
The monthly Clean Ocean Advocate newsletter informs citizens about critical ocean pollution issues, important meeting dates, proposed legislation, special events, and other notes of interest.

core   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

AI and knowledge driven computation of rock mass characteristic parameters across engineering projects

Scientific Reports
With the continuous development of underground construction, represented by transportation tunnels, municipal utility tunnels and hydraulic tunnels, accurately perceiving the rock mass quality ahead of the tunnel boring machine (TBM) face has become ...
Zewang Zheng, Yunpei Zhang, Quan Xu, Kezhong Wang, Changchun Ren, Hao Cai   +5 more
doaj   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Clean Ocean Advocate, September 2009

, 2009
The monthly Clean Ocean Advocate newsletter informs citizens about critical ocean pollution issues, important meeting dates, proposed legislation, special events, and other notes of interest.

core   +1 more source