Results 31 to 40 of about 1,646,307 (265)
Molecular Oncology, EarlyView.Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley +1 more source
Molecular Oncology, EarlyView.Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Small extracellular vesicles are a promising source of diagnostic molecules. We conducted a comprehensive study, including transcriptome profiling and RT‐qPCR validation on large cohorts of samples. Diagnostic panels enabling sensitive detection of colorectal cancer and precancerous lesions were established. Some molecules were differentially expressed
Petra Vychytilova‐Faltejskova +26 more
wiley +1 more source
A brief account of the 2030 agenda and its implications for Brazil and the Amazon Region in achieving Sustainable Development Goal 6: Clean Water and Sanitation [PDF]
, 2022 Simone Bessa de Almeida +1 more
openalex +1 more source
Groundwater and the Sustainable Development Goals (SDGs) [PDF]
, 2018 Groundwater is an important part of the water cycle, but this don’t reflects at all in the indicators for the Sustainable Development Goals (SDGs) of the United Nations (UN).
Chambel, António
core
Molecular Oncology, EarlyView.Proteomic and phosphoproteomic analyses were performed on lung adenocarcinoma (LUAD) tumors with EGFR, KRAS, or EML4–ALK alterations and wild‐type cases. Distinct protein expression and phosphorylation patterns were identified, especially in EGFR‐mutated tumors. Key altered pathways included vesicle transport and RNA splicing.
Fanni Bugyi +12 more
wiley +1 more source
Whole body cleaning agent containing N-acyltaurate [PDF]
, 1992 The subject invention relates to a human cleansing agent particularly suitable for use in long duration spaceflight and to a method of bathing with the agent.
Lentsch, Steven E.
core +1 more source
Closed bipolar electrodes for spatial separation of H2 and O2 evolution during water electrolysis and the development of high-voltage fuel cells [PDF]
, 2017 Electrolytic water splitting could potentially provide clean H2 for a future ‘Hydrogen Economy.’ However, as H2 and O2 are produced in close proximity to each other in water electrolysers, mixing of the gases can occur during electrolysis, with ...
Goodwin, Sean, Walsh, Darren A.
core +2 more sources
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
Economic Impact of the James River Park System [PDF]
, 2017 The James River Park System (JRPS), “a Little Bit of Wilderness in the Heart of the City,” is a unique part of Richmond’s Department of Parks, Recreation and Community Facilities. With 550 acres of shoreline and islands in the capital of the Commonwealth
Shivy, Victoria A., Suen, I-Shian
core +1 more source