Results 31 to 40 of about 359,177 (303)

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

The Correlation between Clean and Healthy Living Behavior and Diarrhea Incidence in Children Under Five Years Old: A Literature Review Study

Jurnal Ilmiah Kesehatan, 2022
Diarrhea is a disease often accompanied by mortality and morbidity. Its incidence increased 1% per year from 300 thousand household samples. Lack of Clean and Healthy Living Behavior (in Indonesia, namely of a program is Perilaku Hidup Bersih Sehat or ...
Dwiana Mei Desti Setyarini, Nur Hidaayah   +1 more
doaj   +1 more source

Impact of UV irradiation at full scale on bacterial communities in drinking water

, 2020
Water in a full-scale drinking water treatment plant was irradiated with ultraviolet (UV) doses of 250, 400, and 600 J/m2, and the effect on bacterial communities investigated using 16s rRNA gene amplicon sequencing, heterotrophic plate counts (HPCs ...
Rådström, Peter, Öhrman, Caroline,, Jacobsson, Karin,, Dryselius, Rikard, Jacobsson, Karin, Salomonsson, Emelie,, Forsman, Mats,, Ahlinder, Jon, Paul, Catherine J., Pullerits, Kristjan, Holmer, Linda, Ahlinder, Jon,, Dryselius, Rikard,, Pullerits, Kristjan,, Paul, Catherine J.,, Forsman, Mats, Öhrman, Caroline, Salomonsson, Emelie, Holmer, Linda,, Lund University.   +19 more
core   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Clean Water Fund ... annual report

, 2002
Annual; 2002-; Title from title screen.; Published in electronic format only as of 2002. Cf.
Connecticut. Clean Water Fund.
core   +1 more source

Clean Water Filter

, 2022
The United Nations Sustainable Development Goal that our group has chosen is #6: Clean Water and Sanitation. Water is vital to human survival. Unfortunately, throughout certain areas of the world, water sources have been contaminated making it difficult ...
Socrates, Einsey, \u2724, An, Fredy, \u2724, Gutierrez, Eddie, \u2724, Roman, Alonso, \u2724   +3 more
core  

Artisanal and small-scale mining methods and the Sustainable Development Goal 6: Perceived implications for clean water supply

, 2022
International audienceThis paper aims to examine methods of artisanal and small-scale mining (ASM) in Ghana, map their perceived impacts on water resources, and analyse the implications of these perceptions for meeting the targets related to Clean Water ...
Vazquez-Brust, Diego Alfonso, Abrefa Busia, Kwaku, Yakovleva, Natalia, Arthur-Holmes, Francis   +3 more
core   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source