Results 61 to 70 of about 2,196,749 (339)

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

open access: yesFEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu   +17 more
wiley   +1 more source

Thermostable neutral metalloprotease from Geobacillus sp. EA1 does not share thermolysin's preference for substrates with leucine at the P1′ position

open access: yesFEBS Letters, EarlyView.
Knowing how proteases recognise preferred substrates facilitates matching proteases to applications. The S1′ pocket of protease EA1 directs cleavage to the N‐terminal side of hydrophobic residues, particularly leucine. The S1′ pocket of thermolysin differs from EA's at only one position (leucine in place of phenylalanine), which decreases cleavage ...
Grant R. Broomfield   +3 more
wiley   +1 more source

Seawater desalination of arid regions: comparing the policy of the Kingdom of Saudi Arabia and Indonesia

open access: yesChinese Journal of Population, Resources and Environment
Problems with clean water in coastal areas alongside an increase in population and community economic activities have diversified community activities. Coastal settlements bordering the high seas are characterized as arid areas with a lack of clean water.
Nur Khafifah Rusni   +3 more
doaj   +1 more source

Kajian Pemasangan Pipa Air Bersih Melayang dalam Air Laut untuk Mendukung Perkembangan Pariwisata di Nusa Ceningan dan Lembongan

open access: yesJurnal Energi Dan Manufaktur, 2020
ir bersih merupakan kebutuhan dasar untuk kehidupan manusia. Demikian pula aktivitas kehidupan di pulau Nusa Ceningan dan Lembongan membutuhkan air bersih.
Made Suarda, I Gusti Komang Dwijana
doaj   +1 more source

What do Indian children drink when they do not receive water?:statistical analysis of water and alternative beverage consumption from the 2005-2006 Indian National Family Health Survey [PDF]

open access: yes, 2015
BACKGROUND: Over 1.2 billion people lack access to clean water. However, little is known about what children drink when there is no clean water. We investigated the prevalence of receiving no water and what Indian children drink instead.
Basu, Sanjay   +5 more
core   +3 more sources

Proposal for a National Blueprint Framework to Monitor Progress on Water-Related Sustainable Development Goals in Europe

open access: yesEnvironmental Management, 2019
The 17 Sustainable Development Goals (SDGs) underpinned by 169 targets presents national governments with huge challenges for implementation. We developed a proposal for a National Blueprint Framework (NBF) with 24 water-related indicators, centered on ...
B. Essex, S. Koop, C. V. Leeuwen
semanticscholar   +1 more source

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

open access: yesMolecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu   +11 more
wiley   +1 more source

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

Achieving cleaner water for UN sustainable development goal 6 with natural processes: Challenges and the future

open access: yesFrontiers in Environmental Science, 2022
UN Sustainable Development Goal 6 aims to achieve clean water for all. Access to clean water is a basic human right but can be costly and challenging.
Lucy Crockford
doaj   +1 more source

Cytomegalovirus infection is common in prostate cancer and antiviral therapies inhibit progression in disease models

open access: yesMolecular Oncology, EarlyView.
Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon   +13 more
wiley   +1 more source

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