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Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source

Mechanical Performance and Durability of Concretes with Partial Replacement of Natural Aggregates by Construction and Demolition Waste

Waste
This study investigated the mechanical performance and durability of concretes produced with varying proportions of recycled coarse aggregate from construction and demolition waste (CDW), ranging from 0% to 100% replacement of natural coarse aggregate ...
Thamires Alves da Silveira +7 more
doaj +1 more source

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

FEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson, Anja H. Schiemann, Evelyn Sattlegger +2 more
wiley +1 more source

Investigation of measurement method of saturation magnetization of iron core material using electromagnet

AIP Advances, 2018
This paper discusses a measurement method for saturation magnetizations of iron core materials using an electromagnet, which can apply an extremely large magnetic field strength to a specimen.
Takuya Shibataki, Yasuhito Takahashi, Koji Fujiwara +2 more
doaj +1 more source

Regulation and physiological function of proteins for heat tolerance in cowpea (Vigna unguiculata) genotypes under controlled and field conditions

Frontiers in Plant Science, 2022
The expression of heat shock proteins is considered a central adaptive mechanism to heat stress. This study investigated the expression of heat shock proteins (HSPs) and other stress-protective proteins against heat stress in cowpea genotypes under field
Tonny I. Selinga +10 more
doaj +1 more source

Safety and Efficacy of GLP‐1 Receptor Agonists in Adults With Epilepsy, Obesity, and Type 2 Diabetes

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Managing obesity in patients with epilepsy is complicated by the weight‐gaining properties of essential antiseizure medications (ASMs) such as valproate and pregabalin. We evaluated the safety and efficacy of initiating glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) in this population.
Hyoshin Son, Inyoung Hwang, Sang Won Lee, Yun Kim +3 more
wiley +1 more source

Cumulative Social Disadvantage and Disease Activity in Juvenile Idiopathic Arthritis: A Childhood Arthritis and Rheumatology Research Alliance Registry Study

Arthritis Care &Research, EarlyView.
Objective Social determinants of health (SDOH) contribute to juvenile idiopathic arthritis (JIA) disparities, but most studies have assessed SDOH independently rather than cumulatively across individual, family, and neighborhood levels. Using a socioecological framework, we investigated the relationship among cumulative social disadvantage ...
William Daniel Soulsby +448 more
wiley +1 more source

Hydrodynamic Characteristics of Two Side-by-Side Cylinders at a Pitch Ratio of 2 at Low Subcritical Reynolds Numbers

Fluids, 2022
Isothermal turbulent flow around circular cylinders arranged side-by-side was numerically simulated on a commercial finite-volumes platform, ANSYS® CFX, version 2020 R2. The turbulence was modeled by using k-ω shear stress transport (k-ω SST).
Thiago Gomes, Jhon Goulart, Carla Anflor
doaj +1 more source

Clinical Validation of Artificial Intelligence (AI)‐based Cartilage Segmentation Predicting Knee Replacement

Arthritis Care &Research, Accepted Article.
Objective For cartilage morphology to serve as a scalable endpoint in clinical trials, analyses should be performed automatically without human interaction. To clinically validate artificial intelligence (AI)‐based analysis, we studied cartilage loss from MRI prior to knee replacement.
Felix Eckstein +3 more
wiley +1 more source

Spatiotemporal Patterns of 45-Day Precipitation in Rio Grande Do Sul State, Brazil: Implications for Adaptation to Climate Variation

Atmosphere
Understanding precipitation variability is essential for assessing climate dynamics and their impacts on agriculture, water resources, and infrastructure.
Luana Centeno Cecconello +3 more
doaj +1 more source